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  1. 1 Open Chemistry

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  1. 1 2012

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  1. 1 Barek J.

  2. 1 Dag C.

  3. 1 Dejmkova H.

  4. 1 Zima J.

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Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode

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Dejmkova H., Dag C., Barek J., Zima J.
Open Chemistry
|
2012
|
vol. 10
|
issue 4
1310-1317
EN
New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 μmol L−1 and 0.015 mmol L−1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle. [...]
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