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A common treatment of bad healing wounds is vacuum assisted therapy (negative pressure wound therapy). The main clinical goal are: reduced time of wound healing, decreasing frequency of septic complications, and better functional and cosmetic effect. One of the main contraidications include a malignant process in the patient, however, it is reported that in some cases it has achieved possitive results. 68 years-old man was admitted to the hospital due to resection of giant anal cancer. Because of severe problems with passing stool, size of the lesions, sphincter infiltration and full dysfunction, according to the patient’s acceptation abdominoperineal rectal resection with end colostomy was performed. An open, non-healed wound was a contraindication for radiotherapy – the most advisable type of treatment in advanced anal cancer. Despite of potential malignancy in the wound, because the non-healed wound delaying the radiotherapy the negative pressure wound therapy was introduced to improve healing, close the wound and enable radiotherapy. Potential benefits and risks of npwt treatment should always be considered. In some selected cases of oncologic patients after the surgery npwt can be considered, especially when our treatment is used in palliative management or even when the proliferation of neoplastic tissues does not affect the duration of life (paliative treatment, morbidity, old age etc.)    
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