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Effect of substrate stiffness on differentiation of umbilical cord stem cells

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Witkowska-Zimny M., Walenko K., Wałkiewicz A. E., Pojda Z., Przybylski J., Lewandowska-Szumieł M.
Acta Biochimica Polonica
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2012
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vol. 59
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issue 2
261-264
EN
Tissue formation and maintenance is regulated by various factors, including biological, physiological and physical signals transmitted between cells as well as originating from cell-substrate interactions. In our study, the osteogenic potential of mesenchymal stromal/stem cells isolated from umbilical cord Wharton's jelly (UC-MSCs) was investigated in relation to the substrate rigidity on polyacrylamide hydrogel (PAAM). Osteogenic differentiation of UC-MSCs was enhanced on stiff substrate compared to soft substrates, illustrating that the mechanical environment can play a role in differentiation of this type of cells. These results show that substrate stiffness can regulate UC-MSCs differentiation, and hence may have significant implications for design of biomaterials with appropriate mechanical properties for regenerative medicine.
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