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  1. 1 Czasopismo Techniczne

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  1. 1 2015

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  1. 1 Mirota K.

  2. 1 Wasilewski J.

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Biomechanical aspects of atherosclerosis

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Wasilewski J., Mirota K.
Czasopismo Techniczne
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PL
Pathogenesis of atherosclerosis is a complex multifactorial process of vascular wall injury. It is widely accepted that the local hemodynamic factors, in particular, disturbed flow and low/ oscillatory shear stress leads to the plaque development. We present a consistent concept of atherosclerosis aetiology, taking into consideration the four main components contributing in the atheroma formation: geometric, hemodynamic, hemorheological, and mechanical risk factors. Exemplary illustrative flow simulation results for formulated concept have been presented. It assumes the pulsatile non-Newtonian fluid flow and uses realistic coronary artery geometry based on medical imaging and segmentation.
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