Aim: The aim of study was test effi cacy of accelerated postoperative radiotherapy – concomitant boost in patients with advanced larynx cancer. Methods and Materials: The prospective study included 112 patients with advanced larynx cancer after radical surgical treatment. Patients had postoperative radiation therapy, conventional (C) or accelerated (CB). Results: The 3-year overall survival in CB was 59%, in C – 58% (p=0,2), 3-year locoregional control in CB – 83%, in C – 75% (p=0.01), the 3-year disease free survival was in CB – 72%, C – 66% (p=0.1). Conclusion: Concomitant boost postoperative radition therapy did not improove overall survival, loco-regional control, disease free survival. Patients with close surgical margins, longer interval between surgery and radiation, high level of hemoglobin, T4 had benefi t from accelerated radiotherapy.
The authors present a case of 64 years old woman treated with palliative radiotherapy due to maxillary sinus cancer – non-operative stage. The cancer-relative pain couldn’t be released after radiotherapy and with pain killers. She used NSAIDs and opioid drugs. Before chemiotherapy she was undertaken intranasal sinus operation as a palliative operation. Maxillary sinus was opened. The pain after operation diminished signifi cantly. She died 2 and a half months later, during chemiotherapy, but free of pain.
The authors present a case of 64 years old woman treated with palliative radiotherapy due to maxillary sinus cancer – non-operative stage. The cancer-relative pain couldn’t be released after radiotherapy and with pain killers. She used NSAIDs and opioid drugs. Before chemiotherapy she was undertaken intranasal sinus operation as a palliative operation. Maxillary sinus was opened. The pain after operation diminished signifi cantly. She died 2 and a half months later, during chemiotherapy, but free of pain.
Aim: The aim of study was test effi cacy of accelerated postoperative radiotherapy – concomitant boost in patients with advanced larynx cancer. Methods and Materials: The prospective study included 112 patients with advanced larynx cancer after radical surgical treatment. Patients had postoperative radiation therapy, conventional (C) or accelerated (CB). Results: The 3-year overall survival in CB was 59%, in C – 58% (p=0,2), 3-year locoregional control in CB – 83%, in C – 75% (p=0.01), the 3-year disease free survival was in CB – 72%, C – 66% (p=0.1). Conclusion: Concomitant boost postoperative radition therapy did not improove overall survival, loco-regional control, disease free survival. Patients with close surgical margins, longer interval between surgery and radiation, high level of hemoglobin, T4 had benefi t from accelerated radiotherapy.
Purpose. Results of treatment of locally advanced larynx cancer T3-4No-4 are unsatisfi ed. The aim of study is analysis of risk factors. Methods and Materials. 112 patiens with larynx cancer after radical surgical treatment had postoperative radiotherapy (conventional or accelarated). Results. The 3-year overall survival (OS) was 58%. Margin status and numer of risk factors had impast on OS. The 3-year locoregional control (LRC) was 80%. Number of risk factors, level of hemoglobin, overall tratment time and dose were signifi cantly associated with LRC. Incidence of distant metastases was asssociated with G3 suamous cell carcinoma and index of nalignancy H. Glanz.
Purpose. Results of treatment of locally advanced larynx cancer T3-4No-4 are unsatisfi ed. The aim of study is analysis of risk factors. Methods and Materials. 112 patiens with larynx cancer after radical surgical treatment had postoperative radiotherapy (conventional or accelarated). Results. The 3-year overall survival (OS) was 58%. Margin status and numer of risk factors had impast on OS. The 3-year locoregional control (LRC) was 80%. Number of risk factors, level of hemoglobin, overall tratment time and dose were signifi cantly associated with LRC. Incidence of distant metastases was asssociated with G3 suamous cell carcinoma and index of nalignancy H. Glanz.
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