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ACE-inhibitors and atherosclreosis

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Gminski J., Stajszczyk M.
Postępy Higieny i Medycyny Doświadczalnej
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1996
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vol. 50
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issue 2
157-171
EN
The activation of the renin-angiotensin system has been proposed as a very important step in the pathogenesis of atherosclerosis. Accordingly, ACE-inhibitors and angiotensin II receptors antagonists showed their ability to reduce the atherosclerotic process in animals. Inhibition of renin-angiotensin system reduces the development of atherosclerotic lesion either in cholesterol-fed animals and in animals after vascular injury. The precise mechanism for this action may depend on the inhibition of other than hypertensive property of angiotensin II.
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