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DNA Ploidy in the Treatment of Stomach Adenocarcinoma: A Follow-Up Study

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Gawrychowski J., Tyczyński A., Danik A., Lackowska B., Koziołek H., Mucha R.
Polish Journal of Surgery
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2007
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vol. 79
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issue 12
753-761
EN
The aim of the study was to determine unfavourable prognostic factors for patients with stomach adenocarcinoma after their surgical treatment through evaluation of prognostic indicators for cellular ploidy and proliferative activity.Material and methods. A group of 51 patients following surgical treatment due to stomach adenocarcinoma and discharged from our hospital between 1995-2000 were studied here. The material examined was encased in paraffin blocks. After histopathological verification, the tumour segments within these blocks were used for cytofluorometric analysis of DNA-ploidy according to Hedley's method.Results. In 41 (80.4%) stomach cancer patients (out of the total group of 51 patients), diploid tumours were found. No significant relationship between DNA ploidy and sex, age, symptoms, inherited susceptibility to a disease, tumour magnitude, grade of histological malignancy, or grade of clinical progression was observed. Generally, after the stomach cancer operation, the probability of five-year survival was 22.1% for patients with diploid tumours (DI=1.0), and 20% for the patients with aneuploid tumours (DI ± 1.0). The probability of 10-year survival was 19.2% for diploid tumours, and 10% for aneuploid tumours. These differences were not statistically significant (p=0.255).Conclusions. 1. Classical clinicopathologic factors are still the best prognostic criteria for the evaluation of long-term results of surgical treatment for stomach cancer patients. 2. Determination of DNA-ploidy and proliferative activity of stomach cancer did not decrease the gap between long-term results prognosis for surgical treatment and actual results.
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DNA Ploidy in the Treatment of Large Bowel Adenocarcinoma: A Follow up Study

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Gawrychowski J., Tyczyński A., Danik A., Lackowska B., Mucha R., Koziołek H.
Polish Journal of Surgery
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2008
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vol. 80
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issue 1
6-13
EN
The aim of the study was to look for unfavourable prognostic features in colorectal cancer patients after their surgical treatment as well as to evaluate the prognostic value of cellular ploidy and proliferative activity.Material and methods. A group of 71 colorectal cancer patients discharged from the hospital after surgical treatment in the years 1995-2000 was studied. The examined material was acquired from paraffin blocks of tumour segments. After histopathological verification, the tumour segments recovered from paraffin blocks were used for cytofluorometric analysis of cellular ploidy according to the Hedley method.Results. Diploid tumours were found in 45 of 71 (63.4%) colorectal cancer patients. No significant relationship between DNA ploidy and sex, age, complications, inherited susceptibility to a disease, tumour magnitude, grade of histological malignancy, or grade of clinical progression was observed. After colorectal cancer surgery, the probability of five- and ten-year survival was 44.4% and 37.1%, respectively, for the patients with diploid tumours (DI=1.0), and 38.5% and 9%, respectively, for the patients with aneuploid tumours (DI≠1.0). These differences were not statistically significant (p=0.120).Conclusions. 1. Classical clinicopathologic factors are still the best prognostic criteria for the evaluation of the future results of colorectal cancer patients' surgical treatment. 2. Determination of cellular ploidy and proliferative activity of colonic adenocarcinoma cannot increase the ability to predict prognosis based on surgical treatment.
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