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Magnetic Resonance Imaging Analysis of Moving Fronts in Floating Dosage Forms

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Kulinowski P., Dorożyński P., Jachowicz R., Jasiński A.
Acta Physica Polonica A
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2005
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vol. 108
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issue 1
155-160
EN
An application of magnetic resonance imaging in the field of pharmaceutical technology is presented in this paper. The analysis of diffusion and swelling fronts was carried out for four floating dosage forms using magnetic resonance imaging. The influence of polymer viscosity, its concentration, and type of applied dissolution media on the area of moving fronts was investigated.
2
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Qualification of the Most Statistically "Sensitive" Diffusion Tensor Imaging Parameters for Detection of Spinal Cord Injury

100%
Krzyżak A., Jasiński A., Adamek D.
Acta Physica Polonica A
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2005
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vol. 108
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issue 1
207-210
EN
Qualification of the most statistically "sensitive" diffusion parameters using Magnetic Resonance (MR) Diffusion Tensor Imaging (DTI) of the control and injured spinal cord of a rat in vivo and in vitro after the trauma is reported. Injury was induced in TH12/TH13 level by a controlled "weight-drop". In vitro experiments were performed in a home-built MR microscope, with a 6.4 T magnet, in vivo samples were measured in a 9.4 T/21 horizontal magnet The aim of this work was to find the most effective diffusion parameters which are useful in the statistically significant detection of spinal cord tissue damage. Apparent diffusion tensor (ADT) weighted data measured in vivo and in vitro on control and injured rat spinal cord (RSC) in the transverse planes and analysis of the diffusion anisotropy as a function of many parameters, which allows statisticall expose of the existence of the damage are reported.
3
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Dynamics of Protein Elements of Hybrid Nanostructures - Molecular Dynamics Simulations of Light Harvesting Peridinin-Chlorophyll a-Protein Model

88%
Jasiński A., Mikulska K., Krajnik B., Mackowski S., Nowak W.
Acta Physica Polonica A
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2012
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vol. 122
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issue 2
284-288
EN
Hybrid nanostructures are often composed of inorganic parts and "biological" ones. Optimized through million years of evolution light harvesting proteins are hard to mimic synthetically. Promising strategy in search for efficient solar cells is an attachment of selected natural protein systems to inorganic quantum dots. Such experimental hybrid structures should have improved charge separation properties. Among the most promising proteins is peridinin-chlorophyll-protein from Amphidinium carterae (PCP). It has a wide absorption spectrum (420-550 nm), optimized for sunlight. The dynamics of this protein, used in modern nanotechnology has been not addressed yet. In this work we present results of PCP computer modeling using a well established molecular dynamics methodology. The CHARMM27 force field parameters were prepared for this protein and all chromophore components. The system was embedded in a box of water, with proper counter ions, and a number of 10 ns molecular dynamics simulations were run using the NAMD code. It has been found that peridinine chromophores exhibit substantial orientational flexibility but a pair Per612 and Per613 is more rigid than the remaining two carotenoids. Orientation and dynamics of absorption and emission electric dipole moments have been also analyzed. Apparently, the architecture of PCP is not optimized for efficient Per-Chl a energy transfer by the Förster mechanism. Several practical issues related to molecular dynamics simulation of similar hybrid nanostructures are discussed.
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