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Diagnosis of paediatric airway foreign body: is it easy?

100%

Rybojad B., Niedzielska G., Rudnicka-Drożak E.

Open Medicine

2014

vol. 9

issue 5

648-652

Foreign-body aspiration in children results in diagnostic problems, mainly because of nonspecific signs. Therefore, in this study, we placed particular stress on false-positive and -negative predictors. Charts of 139 consecutive paediatric patients aged 6.0 months to 15.5 years who underwent bronchoscopy for a suspected foreign body aspiration were analysed retrospectively. A foreign body was found in 95 cases (68%). The anamnesis was positive in 91%. Cough was the most common clinical symptom (91%) with a sensitivity and specificity of 94% and 23%, respectively. There were no significant correlations between clinical symptoms and the locations of foreign bodies. The majority of focal hyperinflation (24%) and atelectasis (15%) were seen in chest radiographs, with a sensitivity and specificity of 33% and 89% (hyperinflation) and 15% and 82% (atelectasis), respectively. Chest X-rays were normal in 46 cases; however, an object was removed in 25. Persistent infiltrates were present in 14 X-rays, and a foreign body was extracted during bronchoscopy in 4. A highly significant correlation between the type of foreign body and radiological signs was noted (p = 0.00001). Anamnesis, clinical symptoms, and radiological findings are helpful in confirming aspiration, but can be misleading. Chronic or recurrent pneumonia should prompt further bronchoscopic diagnosis.

The role of Th17 lymphocytes in pathogenesis of autoimmune arthritides

88%

Pogoda K., Pyszniak M., Bańka M., Rybojad B., Tabarkiewicz J.

Polish Journal of Public Health

2015

vol. 124

issue 1

55-58

Th17 cells are newly described population of lymphoctyes, that recruits neutrophils to the site of inflammation and activate inflammatory phenotype of various tissues. They also play a pivotal role in autoimmune diseases and cancers. These cells secrete mainly different isoforms of IL-17, but also IL-21 and IL-22. Rheumatoid arthritis and juvenile idiopathic arthritis are the most common autoimmune joints’ inflammatory disease, affecting respectively adults and children. For a long time the immunopathogenesis of autoimmune diseases has been associated with Th1 lymphocytes. This hypothesis has changed after the discovery of Th17 cells, which are thought to be key mediators of autoimmune arthritides

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1 Open Medicine

1 Polish Journal of Public Health

2 2014

2 Rybojad B.

1 Bańka M.

1 Niedzielska G.

1 Pogoda K.

1 Pyszniak M.

1 Rudnicka-Drożak E.

1 Tabarkiewicz J.

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Diagnosis of paediatric airway foreign body: is it easy?

The role of Th17 lymphocytes in pathogenesis of autoimmune arthritides