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EN
Glomerular Filtration Rate impairment is an important risk factor of complication after operation. The recognition of Chronic Kidney Disease prior to surgery assists in reducing postoperative complications. This is especially important for arteriosclerotic patients with kidney function impairment, which quite often persist unrecognized. Estimation of the eGFR identify patients with CKD and assist in the planning and modification of treatment.The aim of the study was evaluation of the number of patients with impaired kidney function (eGFR 15-60 ml/min/1.73 m2) from those referred for artery reconstruction. The analysis of early complications related to the impaired GFR.Material and methods. Prospective not-randomized trial of a group of 828 patients who had undergone surgical or endovascular procedures. On admission eGFR was assessed according to the Cockroft-Gault formula. Comparison in frequency and type of early complication was performed between two groups (eGFR ≤ 60 ml/min/1.73 m2 - 536 patients and eGFR 15-60 ml/min/1.73 m2 - 292 patients).Results. Impaired Kidney Function with eGFR in the range between 15- 60 ml/min/1,73 m2, was recognized in 35% of patients. In the impaired eGFR group gastrointestinal bleeding (p<0.0005), acute renal insufficiency (p<0.0005), pneumonia (p<0.05), diabetes decompensation (p<0.005) and myocardial infarct occurred more often (p<0.05) compared to the normal kidney group. Only a few general and local complications were noticed after the aortic arch arteries operations and endovascular procedures. No statistically insignificant differences were observed between both groups.Conclusions. Glomerular Filtration Rate assessment prior to surgery is useful in predicting severe complications after vascular surgery and should be performed on a regular basis.
EN
The aim of the study was to evaluate the presence and distribution of C-reactive protein (CRP) at the site of the abdominal aortic aneurysm (AAA) suck to determine its potential role in AAA ruptureMaterial and methods. Samples of abdominal aortic aneurysms were obtained from 16 patients during elective surgery. These samples were taken from three places at each three levels of the aneurysmal sack: the neck, at the region of maximum diameter and above bifurcation. The cryostat sections were immunostained for CRP visualization using a specific primary mouse monoclonal anti-C-reactive protein antibody. All the specimens were analyzed morphometrically. The data was analized as the ratio of the active surface of the specimen to its total surface in percentage value.Results. No statistically significant differences between CRP concentrations were found that depended on the site of the aneurysmal sack. However, there exists an average linear correlation between CRP concentration, which is defined as the ratio of the active surface of the specimen to its total surface in percentage value, and the thickness of the adjacent thrombus (Pearson's correlation ratio; r=0.42) with statistical significance of (p<0.00001)Conclusions. The detection of C-reactive protein within the aneurismal wall is not solely sufficient to determine its role in the destruction that eventually leads to a large abdominal aortic aneurysm rupture. It is necessary then to prove an association between not only the metabolism of CRP but also the complement system activation and inflammatory cells response.
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