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The influence of aging in one tauopathy: Alzheimer 's disease

100%

Avila J.

Archivum Immunologiae et Therapiae Experimentalis

2004

vol. 52

issue 6

410-413

In this short review, the link between aging and the onset of Alzheimer's disease is discussed. It has been widely suggested that aging is the greatest risk factor for Alzheimer's disease, in which a failure in the insulin signal-transduction pathway could occur with age and, thereby, the assembly of senile plaques and neurofibrillary tangles (two aberrant structures present in Alzheimer's disease) could be promoted. The main component of neurofibrillary tangles is the microtubule-associated protein tau, and the assembly of tau protein appears to occur after its modification by phosphorylation. In this phosphorylation, some protein kinases related to the insulin-transduction pathway could play a role.

Tau phosphorylation and assembly

51%

Gomez-Ramos A., Smith M. A., Perry G., Avila J.

Acta Neurobiologiae Experimentalis

2004

vol. 64

issue 1

33-39

Neurofibrillary tangles, one of the aberrant structures found in the brain of Alzheimer's disease patients are mainly composed of tau in hyperphosphorylated form.Thus, a possible relation between phosphorylation and assembly of tau proteins has been analysed. By doing in vitro studies we have observed that in certain conditions, where compounds from oxidative stress are present, the capacity of tau for self assembly increases upon phosphorylation.

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1 Acta Neurobiologiae Experimentalis

1 Archivum Immunologiae et Therapiae Experimentalis

2 2004

2 Avila J.

1 Gomez-Ramos A.

1 Perry G.

1 Smith M. A.

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The influence of aging in one tauopathy: Alzheimer 's disease

Tau phosphorylation and assembly