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Impact of Menthal Representation of Disease and Wound-Related Subjective Perception of Disease on Convalescence After Surgical Treatment

100%

Stefaniak T., Dziedziul J., Walerzak A., Adamczyk K., Gill D., Vingerhoets A., Babinska D., Trus M., Lachinski A., Śledziński Z.

Polish Journal of Surgery

2011

vol. 83

issue 5

258-263

Compared to open surgery, laparoscopic treatment has been shown to have several advantages, including lower levels of postoperative pain, faster recovery, and better cosmetic results. Nevertheless, the advantages of laparoscopy are being debated as possibly not being merely related to biomedical factors.Material and methods. The study consisted of two sub-studies. In the first study, 150 healthy, previously unoperated volunteers, not employed in the health services, were included. Healthy volunteers, from the latter study, were given questionnaires that presented different sizes of post-operative wounds and examined their perception of the severity of the illnesses that were treated by surgery leading to these wounds. In the second study, data was collected from 65 laparoscopic cholecystectomy patients and 35 patients treated by the open approach cholecystectomy. Patients from the second study were examined prior to operation and 1 month after surgery with a questionnaire evaluating their subjective perception of the disease.Results. Subjective perception of the severity of disease (SPSD) was similar between the laparoscopy and the open approach cholecystectomy patients before the operation (respectively, 6.25±1.7 and 6.06±2.2; ns). At the follow-up, a significant decrease of SPSD among laparoscopy patients was observed (post-op score = 3.28±0.8, p<0.05 in paired t-Student test), but not in the open approach patients (6.42±1.7, ns in paired t-Student test). The volunteers perceived that the disease of the laparoscopically treated patients was less serious than the disease of those treated with open surgery.Conclusions. The authors would like to emphasize that the study presents a new approach to the explanation of the so called "laparoscopy phenomenon", i.e. much faster and smoother recovery after relatively larger and more serious surgical procedures. We believe that the benefits observed among the videoscopy patients might be, apart from immunological and pain-related factors, attributed to the psychological influence of cognitive representations of the disease severity on pain, analgetics use, and recovery.

Dynamics of estrogen-induced oxidative stress

81%

Kobiela J., Stefaniak T., Krajewski J., Kalinska-Blach B., Zurawa-Janicka D., Lachinski A., Gackowski D., Olinski R., Nowak J., Knap N., Lipinska B., Sledzinski Z., Wozniak M.

2007

vol. 54

issue 2

289-295

The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.

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1 Acta Biochimica Polonica

1 Polish Journal of Surgery

1 2011

1 2007

2 Lachinski A.

2 Stefaniak T.

1 Adamczyk K.

1 Babinska D.

1 Dziedziul J.

1 Gackowski D.

1 Gill D.

1 Kalinska-Blach B.

1 Knap N.

1 Kobiela J.

1 Krajewski J.

1 Lipinska B.

1 Nowak J.

1 Olinski R.

1 Sledzinski Z.

1 Trus M.

1 Vingerhoets A.

1 Walerzak A.

1 Wozniak M.

1 Zurawa-Janicka D.

1 Śledziński Z.

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Impact of Menthal Representation of Disease and Wound-Related Subjective Perception of Disease on Convalescence After Surgical Treatment

Dynamics of estrogen-induced oxidative stress