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A case of myositis with immunological background associated with statin use

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Protić D., Baltić S., Stupar N., Pavlov-Dolijanović S., Mugoša S., Todorović Z.

Open Medicine

2014

vol. 9

issue 5

619-624

Statins might cause and/or aggravate the immune-mediated myositis in patients on long-term, stable treatment. We provide a case of polymyositis with an immunological background and gastrointestinal and urinary manifestations in patient on long-term, stable atorvastatin treatment for the past six years. The diagnose of polymyositis was established based on clinical symptoms and signs, electromyography and laboratory test results (elevated aspartate aminotransferase 279 U/L, reference range 0–40 U/L; alanine aminotransferase 198 U/L, 0–33 U/L; lactate dehydrogenase 2200 U/L, 103-227 U/L; creatine kinase 7820 U/L, 15–84 U/L; and positive antinuclear antibodies test, titer of 1:160, with suspect antisynthetase antibodies). Polymyositis was probably related to atorvastatin treatment (Naranjo score, 5). Other probable causes of the myositis were rejected. Coricosteroid therapy, methotrexate and supplementation with vitamin D did not improve the condition. The patient remained bedridden and died two months after the hospital discharge due to the acute myocardial infarction.

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1 Open Medicine

1 2014

1 Baltić S.

1 Mugoša S.

1 Pavlov-Dolijanović S.

1 Protić D.

1 Stupar N.

1 Todorović Z.

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A case of myositis with immunological background associated with statin use