Search results

1

Oreksyny w regulacji homeostazy energetycznej

100%

Skrzypski M., Strowski M. Z., Nowak K. W.

Kosmos

|

2010

|

vol. 59

|

issue 3-4

305-314

EN

The neuropeptide orexin stimulates food intake and energy expenditure by acting on two different receptors isoforms OXR1 and OXR2. Orexin exists in two isoforms, both of which bind to OXR1 and OXR2. Studies on genetic engineered animals, which lack or overexpress orexins or its cognate receptors revealed that orexin may play a role in controlling glucose homeostasis and body weight changes. Observational studies in narcoleptic humans, who display orexin deficiency, also indicate that orexin plays a role in in the pathophysiology of type 2 diabetes mellitus and obesity. The results implicate that orexin may become an interesting therapeutic tool in alleviating metabolic diseases and in controlling body weight. Indeed, application of exogenous orexin in narcoleptic humans alleviates the symptoms associated with the disease. Therefore it is important to broaden our understating about the physiological role of orexin as well as to further evaluate its potential in the context of pathophysiology of metabolic diseases. Our review focuses on the recent discoveries of orexin's role in regulating endocrine and metabolic functions in vivo and in vitro In addition, it summarizes the accumulated knowledge about its possible involvement in the pathophysiology of two endemic metabolic diseases - type 2 diabetes mellitus and obesity.

2

Effect of a mycooestrogen, zearalenone, and a phytooestrogen, coumestrol on the liver membrane insulin receptor of ovariectomized female rats

100%

Nogowski L., Maćkowiak P., Nowak K. W.

|

vol. 40

|

issue 1

147-150

3

Introduction - obesity, the plague of XXI century civilisation

100%

Nowak K. W., Gromadzka-Ostrowska J., Zabielski R.

Kosmos

|

2010

|

vol. 59

|

issue 3-4

279-280

4

Słowo wstępne — otyłość plagą cywilizacji XXI wieku

100%

Nowak K. W., Gromadzka-Ostrowska J., Zabielski R.

Kosmos

|

2010

|

vol. 59

|

issue 3-4

275-278

5

Corticosteroid-binding globulin in serum of western sitatunga (Tragelphaus spekii)

87%

Siwek M., Nowak K. W., Śmiełowski J.

Acta Biochimica Polonica

|

1994

|

vol. 41

|

issue 2

183-184

6

Comparative studies on fish and bird insulin receptors

75%

Nowak K. W., Maćkowiak P., Nogowski L.

|

vol. 40

|

issue 2

231-236

Refine search results

3 Acta Biochimica Polonica

3 Kosmos

3 2010

1 1994

2 1993

6 Nowak K. W.

2 Gromadzka-Ostrowska J.

2 Maćkowiak P.

2 Nogowski L.

2 Zabielski R.

1 Siwek M.

1 Skrzypski M.

1 Strowski M. Z.

1 Śmiełowski J.

Oreksyny w regulacji homeostazy energetycznej

Effect of a mycooestrogen, zearalenone, and a phytooestrogen, coumestrol on the liver membrane insulin receptor of ovariectomized female rats

Introduction - obesity, the plague of XXI century civilisation

Słowo wstępne — otyłość plagą cywilizacji XXI wieku

Corticosteroid-binding globulin in serum of western sitatunga (Tragelphaus spekii)

Comparative studies on fish and bird insulin receptors