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Non-thermal plasma treatment induces MAPK signaling in human monocytes

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Bundscherer L., Nagel S., Hasse S., Tresp H., Wende K., Walther R., Reuter S., Weltmann K.-D., Masur K., Lindequist U.

Open Chemistry

2015

vol. 13

issue 1

The application of non-thermal atmospheric pressure plasma raises a hope for the new wound healing strategies. Next to its antibacterial effect it is known to stimulate skin cells. However, monocytes are also needed for the complex process of a wound healing. This study investigates the impact of plasma on the intracellular signaling events in the primary human monocytes. The proliferative MEK-ERK (MAPK/ERK kinase-extracellular signal-regulated kinase) pathway was activated by short plasma treatment times. In contrast, an induction of the apoptotic JNK (c-Jun N-terminal kinase) cascade as well as activation of caspase 3 were observed after long plasma exposure. These findings indicate that monocytes can be differentially stimulated by plasma treatment and may contribute to the proper wound recovery.

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1 Open Chemistry

1 2014

1 Bundscherer L.

1 Hasse S.

1 Lindequist U.

1 Masur K.

1 Nagel S.

1 Reuter S.

1 Tresp H.

1 Walther R.

1 Weltmann K.-D.

1 Wende K.

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Non-thermal plasma treatment induces MAPK signaling in human monocytes