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1

Oligonucleotide conjugates

100%
Misiura K.
Biotechnologia
|
1994
|
issue 4
55-58
EN
Various molecules are attached to oligonucleotides to make conjugates.Conjugates are specially designed to increase antisense activity by better interaction with target mRNA, better stability against nucleases, and/or permeability to the cells.
2

Antisense oligonucleotides to PAI-1 mRNA as potential agents for therapeutic intervention in cardiovascular diseases

33%
Cierniewski C. S., Pawlowska Z., Pluskota E., Stasiak M., Kobylanska A., Misiura K., Maciaszek A., Koziolkiewicz M., Stec W. J.
Biotechnologia
|
1996
|
issue 4
141-152
EN
In this report we discuss the possibility of using antisense oligonucleotides specific to PAI-1 mRNA to reversibly decrease PAI-1 level in blood plasma and thus prolong a half-life time endogenous plasminogen activators in circulation.
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