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1

Initiation of chromosomes replication of Streptomyces; comparative anatomy of oriC of eubacteria

100%
Zakrzewska-Czerwinska J.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
|
vol. 49
|
issue 1
149-160
2

Streptomyces and Escherichia coli, model organisms for the analysis of the initiation of bacterial chromosome replication

63%
Messer W., Zakrzewska-Czerwinska J.
Archivum Immunologiae et Therapiae Experimentalis
|
2002
|
vol. 50
|
issue 6
391-396
EN
Streptomyces coelicolor A3(2) and Escherichia coli are quite different in their life-style and the structures of their genomes. Streptomyces exhibit complex multicellular development including formation of multigenomic hyphae during growth. These organisms possess a large linear (8.7 Mb) and GC-rich (~72%) chromosome. The genome sequence of S. coelicolor has just been completed. The difference between E. coli and Streptomyces making them an excellent model organisms for a comparison of their replication modes. In this review, we compare initiation of chromosome replication in both organisms. Their replication origins are different in size, but both have DnaA boxes ? a binding motifs for initiator DnaA protein. The two DnaA proteins have practically the same biochemical properties. Many aspects of the control of initiation seem to be similar. A comparison of the two systems thus allows us to define those aspects of replication initiation that are universally used in the eubacterial kingdom.
3

Helicobacter pylori genome organization

63%
Zawilak A., Zakrzewska-Czerwinska J.
Postępy Higieny i Medycyny Doświadczalnej
|
2001
|
vol. 55
|
issue 3
355-367
EN
Helicobacter pylori is a Gram-negative, spiral-shaped pathogenic bacterium that was firstly isolated and cultured from biopsy specimens by Marshall and Warren in 1983.This organism is a human gastric pathogen associated with peptic ulcer disease as well as chronic gastritis. Recent epidemiological studies have demonstrated that H. pylori is a primary risk factor for the development of intestinal type gastric adenocarcinoma. H. pylori is the first bacterium for which the genomes of two unrelated strains (26695 and J99) have been sequenced. The genome of H. pylori is relatively low in size (1.6-1.73 Mb). In this review, we compare the organization of two sequenced H. pylori genomes. A special emphasis on genetic diversity of H. pylori including plasticity zone and cag pathogenicity island has been placed.
4

The vacuolating cytotoxin of Helicobacter pyroli

63%
Przondo-Mordarska A., Zakrzewska-Czerwinska J.
Postępy Higieny i Medycyny Doświadczalnej
|
1996
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vol. 50
|
issue 4
309-320
EN
Helicobacter pylori is now recognized as the major causative agent of chronic superficial gastritis in humans. The virulence factors of H. pylori are still poorly understood. Vacuolating cytotoxin (VacA) is one of the factors that has been identified so far. VacA induces cytoplasmic vacuolation in eukaryotic cells. The vacA gene encodes a precursor protein of 140 kDa which consists of a 33-amino acid signal sequence, the 87 kDa cytotoxin and a 50 kDa C-terminal domain. The 50 kDa domain is involved in translocation of VacA across outer membrane. Sequence analysis of vacA gene derived from different strains of H. pylori revealed the existence of several families of vacA gene allels. Analysis of a clinically isolated strains of H. pylori showed the correlation between presence of specific vacA allels, VacA activity and peptic ulceration
5

Determination of replication initiation site

51%
Zakrzewska-Czerwinska J., Mackiewicz P., Zawilak A., Cebrat S.
Biotechnologia
|
2005
|
issue 3
91-101
EN
Initiation of bacterial chromosome replication is mediated by a single initiator protein ? DnaA which interacts specifically with multiple DnaA boxes located within the origin of replication oriC. We have applied in silico methods: DNA asymmetry, DnaA box distribution and dnaA gene location to identify the putative replication origins in bacterial chromosomes. The three methods identify the same region as a putative origin in more than half of the analyzed chromosomes. The most universal method of putative oriC identification in bacterial chromosomes is DNA asymmetry, although in some cases it is necessary to apply all three methods. Interestingly, most bacterial chromosomes exhibit an overrepresentation of DnaA boxes; they contain at least one cluster of DnaA boxes in the vicinity of the oriC region that is probably involved in controlling replication initiation.
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