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1

Biotechnology to combat reactive oxygen species

100%
Nawrot R., Gozdzicka-Jozefiak A.
Biotechnologia
|
2002
|
issue 2
88-101
EN
Increased generation of reactive oxygen species (ROS) lies at the background of many diseases, including cancer. Numerous experimental data show that ROS play direct and indirect role in induction and promotion of cancer. Antioxidants, such as glutathione, bilirubin, urate, carotenoids, ascorbate, tocopherols, retinol, belong to nonenzymatic protective mechanisms against ROS antioxidents. A number of plants are rich source of egzogenic antioxidants. Genetic engineering methods are used to modify food plants in the hope that it will elevate their antioxidant content. The recent successful developments are -carotene-rich ?golden rice? and tomato. Intake of these plants could contribute to health benefits worldwide.
2

Plant defensins

100%
Nawrot R., Gozdzicka-Jozefiak A.
|
2007
|
issue 2
27-41
EN
Many plants possess antimicrobial peptides (AMP) constitutively expressed or induced after infection. These families of peptides include four cysteine-type peptides: hevein and knottin-type peptides, lipid transfer proteins, plant defensins and thionins. Plant AMP are basic, cystein-rich peptides with molecular masses of approximately 5 kDa. They are mainly identified in perypheral cell layer of plants. These peptides may have an important role to play in the protection of plants from microbial infection, and they might prove to be useful tools for the genetic engineering of fungal and other patogen resistance in transgenic plants. Plant defensins family show very limited sequence conservation.
3

Biotechnology in regenerative and reproductive medicine

81%
Kamieniarz K., Nawrot R., Grajek K., Gozdzicka-Jozefiak A.
Biotechnologia
|
2006
|
issue 2
31-48
EN
Rapid progress in molecular biology, genetics, and mammalian biotechnology has revolutionized diagnostic, therapeutic and reproductive cloning in mammals. Recently, several human gene products have been able to be pharmaceutically explored in transgenic organisms and employed for medical applications. When organs or tissues are irreparably damaged, they may be also replaced with an artificial device or donor organ. Promising and also controversial application for therapeutic and regenerative medicine is stem cells engineering.
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