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Increased Frequency of Ace Gene DD Genotype in Normotensive Male Smokers with Abdominal Aortic Aneurysm

100%

Waliszewski K., Słomski R., Oszkinis G., Majewski W., Pawlaczyk K.

Polish Journal of Surgery

2007

vol. 79

issue 5

368-374

The aim of the study was to assess whether the association between abdominal aortic aneurisms (AAAs) and the angiotensin-converting enzyme (ACE) DD genotype is changed in male smokers.Material and methods. The ACE I/D polymorphism was examined by PCR in 112 subjects with AAA and in 50 control subjects. The frequency of ACE genotypes (II, ID and DD) in the patient group was assessed in subgroups divided on the basis of blood pressure, smoking and sex.Results. A significant increase in the frequency of ACE DD genotypes has been found in all AAA patients studied (odds ratio OR=2.6; range 1.3-5.6, p <0.0002) when compared to the remaining ACE genotypes (ID and II) and the control group. The respective values were higher when all 74 male smokers with AAA were assessed (OR=3.6; p <0.006). No increase in ACE DD genotype frequency was seen in all females (38) and male nonsmokers when compared to the respective control group (n=16) (OR=1.4; p <0.75).In the group of normotensive AAA patients, the proportion of ACE DD genotype in relation to the remaining ACE genotypes (ID and II) was found to be higher than in the general AAA patient population (odds ratio OR=6.14; range 2.5-14.9, p <0.0001). In 32 normotensive male smokers with AAA, the respective values were higher (OR=8.3).Conclusions. An increased frequency of the ACE DD genotype in normotensive male smokers may account in large part for the increase in DD genotype occurrence noted in all AAA patients.

The Use of Duplex Ultrasound Arterial Mapping (DUAM) and Preoperative Diagnostics in Patients with Atherosclerotic Ischaemia of Lower Extremities

86%

Gabriel M., Pawlaczyk K., Szajkowski R., Stefaniak K., Dzieciuchowicz Ł., Krasiński Z.

Polish Journal of Surgery

2012

vol. 84

issue 6

276-284

In spite of the fact duplex Doppler ultrasonography is recognized as an scanning technique equivalent to other imaging methods for preoperative diagnostics of the lower extremity arteries, in many centres its use is limited to screening.The aim of the study was to the determine usefulness of arterial duplex mapping for preoperative diagnostics in patients with peripheral artery occlusive disease (PAOD)Material and methods. In 2008-2009, 103 patients with PAOD symptoms (129 limbs) were examined in a prospective, non-randomized study. DUAM was performed in all limbs, DSA in 90, CT-angio in 29, and revascularisation procedures in 116 limbs.Results. Problems with completing DUAM occurred in 10,1% of cases, including 1.5% of examinations of no diagnostic value. Consistency of DUAM and DSA results was found in 94.6% of cases, and consistency of DUAM results and the range of actually performed ranges was found in 97.8% of cases. Consistency of DUAM and CT-angio results was recorded in 68.0% of cases. The comparison between individual examinations and the actually performed procedures showed consistency of 96.5% for DUAM and 72.4% for CT-angio.Conclusions. DUAM usefulness for detecting and defining lesions in lower extremity arteries is similar to that of DSA and CT-angio. This examination may be successfully used in preoperative diagnostics, particularly for intravascular procedures, which makes possible to reduce exposition to radiation and minimalize diagnostics costs.

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2 Polish Journal of Surgery

1 2012

1 2007

2 Pawlaczyk K.

1 Dzieciuchowicz Ł.

1 Gabriel M.

1 Krasiński Z.

1 Majewski W.

1 Oszkinis G.

1 Stefaniak K.

1 Szajkowski R.

1 Słomski R.

1 Waliszewski K.

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Increased Frequency of Ace Gene DD Genotype in Normotensive Male Smokers with Abdominal Aortic Aneurysm

The Use of Duplex Ultrasound Arterial Mapping (DUAM) and Preoperative Diagnostics in Patients with Atherosclerotic Ischaemia of Lower Extremities