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Optimization of Antioxidant Properties of Creams with Berry Extracts by Artificial Neural Networks

100%
Makarova K., Zawada K., Wagner D., Skowyra J.
Acta Physica Polonica A
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2017
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vol. 132
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issue 1
44-51
EN
Oxidative stress and the excess of free radicals accelerate the ageing process of human skin. The application of skin cream with antioxidant compounds could reduce the damage caused by free radicals. In this work we studied two types of skin creams with extracts from aronia (Aronia melanocarpa), elderberry (Sambucus nigra) and bilberry (Vaccinium myrtillus) because of their high content of anthocyanins, i.e. strong natural antioxidants. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability of the skin creams with berry extracts were studied with ESR spectroscopy. The artificial neural networks were applied to optimize the berry extract concentration and storage time for oil-in-water and water-in-oil creams. Based on experimental results chokeberry and elderberry extracts in oil-in-water cream base revealed higher DPPH radical scavenging ability than in the corresponding water-in-oil. Artificial neural networks predicts maxima of DPPH radical scavenging for 1-week stored elderberry (2.23 mg DPPH/g) and 1-week stored chokeberry (5.84 mg DPPH/g) and bilberry (5.26 mg DPPH/g) 0.76% extracts in oil-in-water creams. The maxima of DPPH radical scavenging for water-in-oil creams were predicted for 6-week stored 0.8% aronia extract, freshly prepared 0.76% bilberry extract and 1-week stored 0.56% elderberry extract. The artificial neural networks predicted values are in good agreement with the experimental values. DPPH-EPR could be combined with artificial neural networks to optimize the extract concentration, and the type of cream base as well as to predict the effect of storage based on a limited number of experiments and samples.
2
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Soft-Mode vs. Localized Moments Regimes of Spin Fluctuations in Itinerant Electron Magnetism

100%
Solontsov A., Lacroix C., Wagner D.
Acta Physica Polonica A
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1997
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vol. 92
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issue 2
359-362
EN
An analysis of different regimes of spin fluctuation behaviour in anharmonic itinerant electron magnets is presented basing on the recently worked out soft-mode theory of spin fluctuations.
3

Mechanisms of Mycobacterium avium pathogenesis

100%
Bermudez L. E., Wagner D., Sosnowska D.
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vol. 48
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issue 5
521-528
EN
Infections caused by M. avium are common in AIDS patients and patients with chronic lung diseases. The bacterium can be acquired both by the intestinal route and respiratory route. M. avium is capable of invading mucosal epithelial cells and translocate across the mucosa. The bacterium can infect macrophages interfering with several functions of the host cell. The host defense against M. avium is primarily dependent on CD4+ T lymphocytes and NK cells. Activated macrophages can inhibit or kill intracellular bacteria by mechanisms that are currently unknown but M. avium can invade resting macrophages and suppress key aspects of its function by triggering the release of TGF-beta and IL-10. Co-infection with HIV-1 appears to be mutually beneficial with both organisms growing faster.
4
Content available remote

Special X-Ray Silicon Detectors for Medical Applications

64%
Halmagean E., Wagner D., Tsoi E., Misiakos K., Ohanisian M., Veron A., Cimpoca V., Lazarovici D.
Acta Physica Polonica A
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1997
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vol. 91
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issue 4
789-792
EN
The paper presents some results concerning the technology and behaviour of X-ray silicon detectors intended for controlling low radiation levels in interventional cardiology. An improved planar process was used for obtaining large area guard-ring test structures. The electrical characteristics, their modification after exposure to radiation and the results of spectroscopic X-ray measurements are discussed.
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