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  1. 2 Open Chemistry

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  1. 1 2012

  2. 1 2011

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  1. 2 Yordanov G.

  2. 1 Bedzhova Z.

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Development of cephalexin-loaded poly(ethyl cyanoacrylate) colloidal nanospheres

100%
Yordanov G.
Open Chemistry
|
2012
|
vol. 10
|
issue 2
305-312
EN
This article considers the preparation and physicochemical characterization of a novel colloidal formulation of the β-lactam antibiotic cephalexin, loaded in poly(ethyl cyanoacrylate) colloidal nanospheres. The drug was loaded by means of drug incorporation in the interior of poly(ethyl cyanoacrylate) particles during the polymerization of the respective monomer in aqueous medium. The obtained colloids were characterized by scanning electron microscopy, dynamic and electrophoretic light scattering, Fourier transform infrared and nuclear magnetic resonance spectroscopy. It was found that the drug loading efficiency depends on the initial concentration of monomer and cephalexin in the polymerization medium. The average size of cephalexin-loaded particles was around 400 nm and did not depend significantly on the concentrations of drug and monomer. Drug-loaded particles with drug content as high as 21% (w/w) were prepared. The drug release kinetics was studied in physiological phosphate-buffered saline. It was found that a biexponential model could describe well the experimental release kinetics. [...]
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Poly(ethyl cyanoacrylate) colloidal particles tagged with Rhodamine 6G: preparation and physicochemical characterization

63%
Yordanov G., Bedzhova Z.
Open Chemistry
|
2011
|
vol. 9
|
issue 6
1062-1070
EN
This paper describes the preparation and characterization of poly(ethyl cyanoacrylate) colloidal particles loaded with the organic fluorophore Rhodamine 6G. We studied the physicochemical properties of the colloidal particles: morphology, size-distribution, ζ-potential, fluorescent properties and photobleaching upon UV-light illumination. The properties of the obtained colloidal particles, as well as the dye loading efficiency, were found to depend on the concentrations of ethyl cyanoacrylate monomer and Rhodamine 6G in the polymerization medium. The fluorophore release from the colloidal particles in aqueous buffer is also studied. [...]
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