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  1. 1 Postępy Higieny i Medycyny Doświadczalnej

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  1. 1 2002

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  1. 1 Zagrodzki P.

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Tioredoxin reductase ? a new target for molecular medical investigations

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Zagrodzki P.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
|
vol. 56
|
issue 2
155-167
EN
Thioredoxin reductase (TrxR) is the first selenoenzyme containing selenocysteine in the active center and FAD as a second prosthetic group. TrxR catalyses the NADPH-dependent reduction of tioredoxin and of many other physiologically important substrates. TrxR exhibits many-fold increased activity in tumor cells and stimulates their proliferation as well the phenotype changes. Some gold compounds and a number of other clinically and experimentally used drugs have been shown to inhibit TrxR. The involvement of TrxR/Trx/NADPH system in broad spectrum of cellular processes renders it potential target for therapeutic approaches.
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