Prolong changes in climatic parameters may affect not only the geographical distribution of various vector borne diseases, but also is projected to have adverse effects on human health with regard to infectious diseases, particularly malaria. Malaria is perceived as the world’s most devastating infectious disease, and is responsible for very high morbidity and mortality. A number of socioeconomic, environmental and behavioral factors affect the disease prevalence. Despite these factors, the impact of climate on probability of malaria transmission remains contentious.
Renin angiotensin aldosterone system (RAAS) is a hormone regulatory hormone system that regulate blood pressure. The two major genes ACE and AGT are the players of RAAS pathway. These genes codes for angiotensin convertase enzyme and angiotensinogen protein respectively. The angiotensin convertase enzyme convert inactive angiotensinogen into active angiotensin which further helps in the regulation of blood pressure. Due to imbalance in this pathway may cause hypertension. So in the present study we decided to perform the computational study of ACE and AGT gene. We evaluated the deleterious/damaging effect of SNPs of ACE and AGT gene by SIFT and I-Mutant2.0. The total number of SNPs predicted to be deleterious by both tools were 5 (1.83%) and 22 (6.07%) for AGT and ACE genes respectively. We also studied subcellular location of ACE and AGT genes and drugs targeting these genes from database GeneCards. Further the result output of both the softwares were also compared.
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