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FUNCTIONAL THREE-COMPONENT POLYMERIC BIOCOMPOSITES FOR THE TREATMENT OF BEDSORES

100%
Wiśniewska-Wrona M., El Fray M.
Progress on Chemistry and Application of Chitin and its Derivatives
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2018
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vol. 23
185 - 206
EN
Presented here are the results of investigations into the preparation of three-component dressing materials from various biopolymers in the form of a single-layer film which is suitable as a carrier for pain-relieving (lidocaine) and bacteriostatic (sulphanilamid) therapeutic agents. Physical-chemical, biological and usable properties of the prepared materials were tested and assessed. The amount of added active substance was adopted based on the dose recommended by the Polish Pharmacopeia for external medicinal preparations. Antibacterial activity against gram (-) Escherichia coli and gram (+) Staphylococcus aureus was assessed in some of the biocomposites by quantitative methods. The cytotoxic action in direct contact with the mouse fibroblast NCTC clone 929 was also estimated. Thermal analysis (DSC), infrared spectrophotometry (FTIR) and nuclear magnetic resonance spectroscopy were employed to investigate the impact of the variable contents of chitosan, alginate, carboxymethyl cellulose (CMC), and the active substance upon the chemical- and phase-structure of the prepared three-component polymeric biocomposites. It was found that the quantitative composition of the biocomposites and the additive of active substances lidocaine and sulphanilamide exert a vital impact upon their physical-mechanical and usable properties (imbibition, absorption). Investigations into the release of the medicinal substance from the investigated biocomposites to an acceptor fluid led to the conclusion that the kinetics of the process may be described by a complex first order rate equation with two exponential functions.
2
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NOVEL CHITOSAN DERIVATIVES AS FILMS WITH AN ANTIMICROBIAL EFFECT

100%
Niemczyk A., El Fray M.
Progress on Chemistry and Application of Chitin and its Derivatives
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2013
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vol. 18
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issue 18
59-66
EN
This paper presents the results of chitosan acylation with linoleic (LA) and dilinoleic acid (DLA). The chemical structures of the new derivatives with different degrees of substitution of LA and DLA were assessed by Fourier transform infrared spectroscopy. Polymer films were prepared by solution casting and drying. The resistance of films to bacterial degradation was tested according ISO 846 standard: “Plastic-Evaluation of the Action of Microorganisms” and the antimicrobial properties were assessed using Gram-negative bacterium Escherichia coli and the fungi Candida albicans in an agar diffusion test. Bioassays showed an antimicrobial effect in direct contact with the material.
3
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CHEMICAL MODIFICATION OF CHITOSAN WITH FATTY ACIDS

81%
El Fray M., Niemczyk A., Pabin-Szafko B.
Progress on Chemistry and Application of Chitin and its Derivatives
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2012
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vol. 17
29 - 36
EN
This paper presents the results of chitosan modification with fatty acids, namely linoleic and oleic acid. We used carbodiimide as the initiator for the reaction of carboxyl and aminoglycoside functional groups. The analysis of infrared spectra confirmed the formation of chitosan derivatives. Their hydrophilic-hydrophobic properties were determined by O/W emulsification and micelles formation in aqueous systems.
4
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SPIN-COATED CHITOSAN ON COPOLYESTER SUBSTRATES

81%
Niemczyk A., Kaczorowski P., El Fray M.
Progress on Chemistry and Application of Chitin and its Derivatives
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2015
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vol. 20
236-245
EN
In this work, uniform thin chitosan coatings were spin coated onto copolyester substrate. The use of high concentration acetic acid (50 wt.%) as the chitosan solvent increased the protonation of chitosan amino groups, allowing for greater interactions between the solution and the surface of the substrate. Further, surface oxidation was used to incorporate additional functional groups in the copolyester surface, facilitating solution/substrate interactions. The interfacial interactions between the chitosan solution and copolyester substrate were evaluated by the contact angle measurements.
5
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THE INFLUENCE OF C18-FATTY ACIDS ON CHEMICAL STRUCTURE OF CHITOSAN DERIVATIVES AND THEIR THERMAL PROPERTIES

81%
Niemczyk A., Kmieciak A., El Fray M., Piegat A.
Progress on Chemistry and Application of Chitin and its Derivatives
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2016
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vol. 21
165-175
EN
Chitosan derivatives with a series of fatty acids (FA) have been developed using simultaneous N- and O-acylation reaction by the combination of two ways of conducting the reaction, i.e. a carbodiimide catalysis and ionic amino group protection. The chemical structure of chitosan derivatives as well as the characterization of the FA substitution degree were done by the IR spectra analysis. The correlation between the substitution of the chitosan functional groups as well as the saturation of FA and the changes of structural and thermal properties of the derivatives has been presented.
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