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Intracranial meningioma in a patient with osteogenesis imperfecta

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Tsitsopoulos P., Anagnostopoulos I., Tsitouras V., Venizelos I., Tsitsopoulos P.
Open Medicine
|
2008
|
vol. 3
|
issue 4
517-520
EN
Osteogenesis imperfecta (OI) is a heritable disorder characterized mainly by connective tissue manifestations. In dinstinct cases, several neurological features have also been described. A 46-year-old male with a known family history of OI type I presented with progressive gait disturbances and diminished muscle strength. Brain MRI scans revealed an infiltrative intracranial mass occupying both frontoparietal lobes. The patient underwent surgical intervention. The histological diagnosis was an atypical (Grade II) meningioma. The bony parts demonstrated a mixture of osseous defects due to OI and infiltration by the tumor. At one-year follow up the patient′s muscle power partially returned while repeat MRI scans were negative for tumor recurrence.
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