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Sjogren's syndrome: An old tale with a new twist

100%

Lee B. H., Tudares M. A., Nguyen C. Q.

Archivum Immunologiae et Therapiae Experimentalis

2009

vol. 59

issue 1

57-66

Sjogren's syndrome (SjS) is chronic autoimmune disease manifested by the loss of saliva and/or tear secretion by salivary and/or lacrimal glands, respectively. The pathogenesis of the disease remains elusive, perhaps due to the multiple triggers of the disease. However, substantial advances have been made in attempting to resolve the complexity of SjS using both animal models and human subjects. The primary objectives of this review are to provide a better understanding of the disease processes with major emphasis on the use of mouse models, how genetic predisposition plays a role in the natural history of the disease, as well as a presentation of new findings pertaining to the role of TH1, TH2, and TH17 cells in the pathogenesis of SjS.

Atomistic Analysis Of Radiation-Induced Segregation In Ion-Irradiated Stainless Steel 316

88%

Lee G.-G., Jin H.-H., Chang K., Lee B. H., Kwon J.

Archives of Metallurgy and Materials

2015

issue 2

Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats

64%

Lee K. H., Suh-Kim H., Choi J. S., Jeun S.-S., Kim E. J., Kim S.-S., Yoon D. H., Lee B. H.

Acta Neurobiologiae Experimentalis

2007

vol. 67

issue 1

13-22

Many attempts have been made in animals to produce cellular regeneration in the spinal cord using a variety of transplanted cell types. The present study was to investigate whether transplantation of human mesenchymal stem cells (hMSCs) into the spinal cord after contusion injury promotes a functional outcome. Spinal cord injury (SCI) was induced using an NYU impactor and hMSCs were transplanted 1 week after SCI. Behavioral testing was performed weekly for 2 months. Somatosensory (SSEPs) and motor evoked potentials (MEPs) were recorded to determine functional recovery. Hindlimb performance was modestly improved in the transplanted group based on BBB scaling and pain tests. SSEP latencies in the transplanted group were significantly shorter than in the media-treated group. Pathologically, LacZ and hTau positive cells were located at the injury and adjacent sites. The data indicate improvement in functional outcome in animals treated with hMSC transplantation compared to media-treated animals.

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1 Acta Neurobiologiae Experimentalis

1 Archives of Metallurgy and Materials

1 Archivum Immunologiae et Therapiae Experimentalis

1 2015

1 2009

1 2007

3 Lee B. H.

1 Chang K.

1 Choi J. S.

1 Jeun S.-S.

1 Jin H.-H.

1 Kim E. J.

1 Kim S.-S.

1 Kwon J.

1 Lee G.-G.

1 Lee K. H.

1 Nguyen C. Q.

1 Suh-Kim H.

1 Tudares M. A.

1 Yoon D. H.

Search results

Sjogren's syndrome: An old tale with a new twist

Atomistic Analysis Of Radiation-Induced Segregation In Ion-Irradiated Stainless Steel 316

Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats