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Inclusion body myositis - a case based clinicopathological update

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Bodoki L., Vincze M., Griger Z., Csonka T., Murnyák B., Kurucz A., Dankó K., Hortobágyi T.

Open Medicine

2014

vol. 9

issue 1

80-85

Inclusion body myositis is a slowly progressive myopathy affecting predominantly the middle-aged and older patient population. It is a major form of the idiopathic inflammatory myopathies which are chronic systemic autoimmune diseases characterized by symmetrical proximal muscle weakness. Unfortunately, there is no effective therapy yet; however, the early diagnosis is essential to provide treatment options which may significantly slow the progression of the disease. In our case-based clinicopathological study the importance of the close collaboration between the clinician and the neuropathologist is emphasised.

Inclusion body myositis – pathomechanism and lessons from genetics

100%

Murnyák B., Bodoki L., Vincze M., Griger Z., Csonka T., Szepesi R., Kurucz A., Dankó K., Hortobágyi T.

Open Medicine

2014

vol. 10

issue 1

Inclusion body myositis is a rare, late-onset myopathy. Both inflammatory and myodegenerative features play an important role in their pathogenesis. Overlapping clinicopathological entities are the familial inclusion body myopathies with or without dementia. These myopathies share several clinical and pathological features with the sporadic inflammatory disease. Therefore, better understanding of the genetic basis and pathomechanism of these rare familial cases may advance our knowledge and enable more effective treatment options in sporadic IBM, which is currently considered a relentlessly progressive incurable disease.

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2 Open Medicine

1 2015

1 2014

2 Bodoki L.

2 Csonka T.

2 Dankó K.

2 Griger Z.

2 Hortobágyi T.

2 Kurucz A.

2 Murnyák B.

2 Vincze M.

1 Szepesi R.

Search results

Inclusion body myositis - a case based clinicopathological update

Inclusion body myositis – pathomechanism and lessons from genetics