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1

Phorbol ester and central chemosympathectomy augment beta-adrenoceptor response by different mechanisms

100%
Nalepa I., Vetulani J.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 2
167-175
EN
The aim of this study was to compare the mechanisms of increased responsiveness of the beta-adrenoceptor dependent cyclic AMP generating system induced by chronic decrease of noradrenaline availability (beta-upregulation) with that resulting from simultaneous stimulation of alfa-adrnoceptors (alfa-potentiation) and to assess the role of portein kinase C in these phenomena. The beta-upregulation was produced by central chemosympathectomy with 6-hydroxydopamine>. The role of alfa1- and alfa2-adrenoceptors was assessed by comparison of the effects of specific beta-adrenoceptor agonist isoproterenol with those of a mixed alfa-beta-adrenoceptor agonist noradrenaline and clonidine was used to selectively stimulate alfa1-adrenoceptors. The role of protein kinase C was assessed by measuring cyclic AMP responses in the presence and absence of 12-O-tetradecanoyl-phorbol 13-acetate. The results indicate that the mechanism of increased responsiveness induced by central chemosympathectomy is different from the alfa-potentiation, that only alfa1-adrenoceptors are involved positively in alfa-potentiation, while the alfa1-adrenoceptors play an inhibitory role, and that increased responsiveness following central chemosympathectomy may be inhibited by protein kinase C activation.
2

The effect of calcium channel blockade on the action of chronic ECT and imipramine on responses of alpha-1 and beta-adrenoceptors in the rat cerebral cortex

100%
Nalepa I., Vetulani J.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 2
201-205
EN
Chronic co-administration of nifedipine and ECT or imipramine results in an increase in responsiveness of cerebral cortical alfa1-adrenoceptor as measured by accumulation of inositol phosphate in cortical slices after noradrenaline stimulation; the responsiveness of beta-adrenoceptor, measured by accumulation of cyclic AMP, was depressed similarly by antidepressant treatment with and without nifedipine.
3
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Jerzy Vetulani (1936-2017). O mentorze, przyjacielu i niepokornym wirtuozie naukowej narracji

71%
Nalepa I., Antkiewicz-Michaluk L., Kreiner G., Pyza E., Zawilska J.
Kosmos
|
2018
|
vol. 67
|
issue 2
233-244
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