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Theoretical and experimental research of anti-tank kinetic penetrator ballistics

100%
Motyl K., Zygmunt B., Magier M., Borkowski J.
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2017
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issue 3
2

Serum concentrations of MCP-1 and RANTES in patients during aortic surgery: the relationship with ischemia-reperfusion

88%
Jedynak M., Siemiatkowski A., Gacko M., Mroczko B., Borkowski J.
Archivum Immunologiae et Therapiae Experimentalis
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2004
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vol. 52
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issue 3
201-207
EN
Surgical trauma is associated with depression of the immune system, which results in a high complication rate following abdominal aortic aneurysm (AAA) repair. Monocyte chemotactic protein-1 (MCP-1) and regulated-on-activation normal T cell expressed and secreted (RANTES) protein are important mediators of the immune and inflammatory response. The aim of this study was to determine whether there is any relationship between MCP-1 or RANTES and operative injury and ischemia-reperfusion during AAA surgery in human. Peripheral blood samples were taken from 12 patients before surgery, after anesthesia induction, before unclamping of aorta (PreXoff), 90 min after unclamping (90minXoff), and at 24 and 48 h after surgery. The MCP-1 and RANTES serum concentrations were measured with the ELISA technique. MCP-1 concentration significantly increased after reperfusion (90minXoff) in comparison with the PreXoff level (p=0.001). Twenty-four hours after AAA repair, MCP-1 significantly decreased 269?225 pg/ml (p=0.005) and reached preoperative value. RANTES level was higher in AAA patients before surgery than in controls (p=0.025) and decreased significantly after ischemia-reperfusion to 13 ng/ml (p< 0.001) at 90minXoff. We showed increases in RANTES concentration to 26 ng/ml on the 1st and to 31 ng/ml on the 2nd day after surgery (p=0.020, p=0.012, respectively) compared with the 90minXoff level. Ischemia-reperfusion during AAA repair results in an increase in MCP-1 and decrease in RANTES concentrations in serum. The changes in chemokine concentrations may influence the development of immunosuppression after AAA repair, contributing to the postoperative course.
3

Soluble selectin profiles associated with severe trauma

88%
Siemiatkowski A., Rogowski F., Wereszczynska-Siemiatkowska U., Malinowska L., Borkowski J.
Archivum Immunologiae et Therapiae Experimentalis
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2001
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vol. 49
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issue 4
317-324
EN
Severe trauma acts as a trigger for the complex cascade of postinjury events leading to the re-lease of different mediators and the development of generalized inflammation. Selectins are a family of adhesion proteins that are responsible for the adherence of polymorphonuclear neu-trophils to the endothelium. This interaction plays an important role in the development of severe complications after multiple trauma. The aim of the present study is to follow the sequential altera-tions in circulating selectins level after severe injury and to evaluate the clinical significance of these mediators in monitoring prognosis and outcome. Thirty four severely traumatized patients were entered into the study. Serum sE-selectin, plasma sP-selectin and sL-selectin concentrations were me-asured and an APACHE II score was calculated on admission to the intensive care unit and during the subsequent 5 days. The patients were divided into survivors and nonsurvivors. Initial soluble P- and E-se-lectin concentrations were significantly elevated in all trauma patients. The highest values of these adhesion molecules were measured in all the observed days in patients with poor prognosis and outcome. In survivors we found a systematic decrease in the sP-selectin concentrations. On admission, the sL-selectin concentrations in all trauma patients were decreased. There were stable, very low values in non-survivors and a slow increase in circulating L-selectin in pa-tients who survived. The pattern of soluble selectins in patients with severe trauma is characterized by increased levels of P- and E-selectin and a decreased concentration of L-selectin. These findings suggest a widespread microvascular en-dothelial activation on injury in the early posttrau-matic period, which may be associated with in-creased neutrophil ? endothelial adhesion, neutrophil extravasation and migration. We sup-pose that these parameters of endothelial cell activation/injury may be useful as another early prognostic factor in severe trauma.
4
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Transient Photo-Induced Current Measurements in High Resistivity ZnSe Crystals

88%
Bała W., Firszt F., Dul D., Turlo Z., Borkowski J.
Acta Physica Polonica A
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1991
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vol. 79
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issue 2-3
295-298
EN
Using technique of computerized signal-averaging of photocurrent transient, we have studied the details of deep level states in high resistivity ZnSe crystals. The time resolved spectra of photocurrent and four-gate PICT spectra are presented.
5
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Optimization of Salmonella Enteritidis recombinant heat shock protein 60 production

76%
Stefaniak T., Rainczak K., Bajzert J., Galli J., Selera A., Wieliczko A., Borkowski J.
Polish Journal of Veterinary Sciences
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2011
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issue 1
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