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Littoral cell angioma mimicking metastatic tumors

100%

Szumilo J., Ostrowska A., Zdunek M., Rudzki S., Chroscicki T., Czekajska-Chehab E., Burdan F.

Current Issues in Pharmacy and Medical Sciences

2015

vol. 28

issue 4

247-249

Littoral cell angioma is a rare primary, vascular tumor thought to originate from the endothelial cells lining the sinuses of the splenic red pulp (the “littoral cells”). It is a benign, usually asymptomatic lesion diagnosed incidentally. Ultrasound and tomography appearance is not characteristic and histopathological examination is required. This work provides a case-study of littoral cell angioma which was seen in a 55-year-old female who complained of non-specific upper abdominal pain. Computed tomography revealed multiple hypo-attenuated splenic lesions suggestive for metastasis. A splenectomy was performed and routine microscopic examination supported by immunohistochemistry reactions with CD68, CD34 and CD31 showed littoral cell angioma.

Organ and prenatal toxicity of nonsteroidal anti-inflammatory drugs

68%

Dyndor K., Dworzanski W., Pliszczynska-Steuden M., Cendrowska-Pinkosz M., Chroscicki T., Dyndor P., Dworzanska A., Piasek E., Piech P., Ruchala M., Golec K., Hermanowicz-Dryka T.

Current Issues in Pharmacy and Medical Sciences

2015

vol. 28

issue 3

200-203

Non-selective cyclooxygenase (COX) inhibitors, commonly referred to as nonsteroidal anti-inflammatory drugs (NSAIDs), are among the most taken pharmaceuticals. In adults, they can have a series of side effects, including especially gastroenterotoxicity, hepatotoxicity, nephrotoxicity, chondrotoxicity, and neurotoxicity, and they can induce allergic reactions. Any exacerbation of symptoms depends on the chemical structure of the drug, its dosage and duration of exposure, individual sensitivity, comorbidities and the degree of inhibition of basic COX isoenzymes - the constitutive (COX-2) and induced (COX-1) expressions. However, data on prenatal toxicity are inconsistent. Classic nonselective COX inhibitors do not result in an increase in the risk of developing significant congenital defects; however, if used in the late-pregnancy period, they can have an adverse effect on the foetus, by inducing the premature closure of the ductus arteriosus and by producing a tocolytic effect. Individual reports also indicate the increased risk of developing heart and anterior abdominal wall defects, as well as hypospadias.

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2 Current Issues in Pharmacy and Medical Sciences

2 2015

2 Chroscicki T.

1 Burdan F.

1 Cendrowska-Pinkosz M.

1 Czekajska-Chehab E.

1 Dworzanska A.

1 Dworzanski W.

1 Dyndor K.

1 Dyndor P.

1 Golec K.

1 Hermanowicz-Dryka T.

1 Ostrowska A.

1 Piasek E.

1 Piech P.

1 Pliszczynska-Steuden M.

1 Ruchala M.

1 Rudzki S.

1 Szumilo J.

1 Zdunek M.

Search results

Littoral cell angioma mimicking metastatic tumors

Organ and prenatal toxicity of nonsteroidal anti-inflammatory drugs