Search results

Sort By:

Limit search:

The thermodynamic dissociation constant of naphazoline by the regression analysis of potentiometric data

100%

Meloun M., Ferenčíková Z., Netolická L., Vrána A.

Open Chemistry

2011

vol. 9

issue 1

66-74

The mixed dissociation constant of naphazoline is determined at various ionic strengths I [mol dm−3] in the range of 0.01 to 0.26 and at temperatures of 25°C and 37°C using ESAB and HYPERQUAD regression analysis of the potentiometric titration data. A strategy of efficient experimentation is proposed in a protonation constant determination, followed by a computational strategy for the chemical model with a protonation constant determination. Two group parameters, L 0 and H T were ill-conditioned in the model and their determination is therefore uncertain. These group parameters, L 0 and H T, can significantly influence a systematic error in the estimated common parameter pKa and they always should be refined together with pK a. The thermodynamic dissociation constant pK aT was estimated by nonlinear regression of {pK a, I} data at 25°C and 37°C: for naphazoline pK alT = 10.41(1) and 10.13(2). Goodness-of-fit tests for various regression diagnostics enabled the reliability of the parameter estimates to be found. [...]

Refine search results

1 Open Chemistry

1 2011

1 Ferenčíková Z.

1 Meloun M.

1 Netolická L.

1 Vrána A.

Search results

The thermodynamic dissociation constant of naphazoline by the regression analysis of potentiometric data