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1

Genetic polymorphism of beta 2-adrenoceptor and its role in pathology

100%
Woszczek G., Kowalski M. L.
Postępy Higieny i Medycyny Doświadczalnej
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2001
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vol. 55
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issue 1
37-51
EN
A few polymorphic loci has recently been identified in the beta 2-adrenoceptor gene that significantly influence receptor expression and its functions. Gene structure, regulation of the receptor expression and functions in regards to genetic polymorphisms and pathology are described.
2

Leukotrienes ? mediators of inflammation

81%
Woszczek G., Pawliczak R., Kowalski M. L.
|
EN
Leukotrienes are biologically active metabolites derived from arachidonic acid playing an important role in inflammatory responses. There are two main groups of leukotrienes: dihydroxy-leukotrienes (LTB4) and cysteinyl-leukotrienes (LTC4, LTD4, LTE4). By activating specific G-protein coupled receptors, leukotrienes take part in immune responses, like activation and chemotaxis of leukocytes. Several studies have shown that leukotrienes may play a significant role in pathomechanisms of inflammatory diseases of human airways, skin, digestive tract and heart.
3

A protective role of HLA-DR locus in patients with various clinical types of alopecia areata

61%
Broniarczyk-Dyla G., Prusinska-Bratos M., Dubla-Berner M., Arkuszewska C., Borowiec M., Kowalski M. L., Woszczek G.
Archivum Immunologiae et Therapiae Experimentalis
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2002
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vol. 50
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issue 5
333-336
EN
One of genetic factors associated with the development of alopecia areata (AA) is HLA locus. The study comprised 52 patients with AA, aged 10 to 64 years. The frequences of HLA-DR B alleles in patients and controls were compared. The control group comprised 152 healthy persons. Familiar occurrence of alopecia areata was seen in 7 cases (13.5%). Significantly lower frequency of HLA-DRB1*03 was observed in patients with AA in comparison to control group. In all patients with AA alleles HLA-DRB1*15/*16 occurred more frequently than in control group, but it was not significant after correction. In the group of patients with more severe form of alopecia areata (AAT/U) there was no significant difference in HLA- DR alleles distribution
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