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1

The multigene family of fatty acid-binding proteins (FABPs): Function, structure and polymorphism

100%
Chmurzynska A.
Journal of Applied Genetics
|
2006
|
vol. 47
|
issue 1
39?48
EN
Fatty acid-binding proteins (FABPs) are members of the superfamily of lipid-binding proteins (LBP). So far 9 different FABPs, with tissue-specific distribution, have been identified: L (liver), I (intestinal), H (muscle and heart), A (adipocyte), E (epidermal), Il (ileal), B (brain), M (myelin) and T (testis). The primary role of all the FABP family members is regulation of fatty acid uptake and intracellular transport. The structure of all FABPs is similar ? the basic motif characterizing these proteins is ?-barrel, and a single ligand (e.g. a fatty acid, cholesterol, or retinoid) is bound in its internal water-filled cavity. Despite the wide variance in the protein sequence, the gene structure is identical. The FABP genes consist of 4 exons and 3 introns and a few of them are located in the same chromosomal region. For example, A-FABP, E-FABP and M-FABP create a gene cluster. Because of their physiological properties some FABP genes were tested in order to identify mutations altering lipid metabolism. Furthermore, the porcine A-FABP and H-FABP were studied as candidate genes with major effect on fatness traits.
2

Cytogenetic mapping of DGAT1, PPARA, ADIPOR1 and CREB genes in the pig

33%
Szczerbal I., Lin L., Stachowiak M., Chmurzynska A., Mackowski M., Winter A., Flisikowski K., Fries R., Switonski M.
Journal of Applied Genetics
|
2007
|
vol. 48
|
issue 3
73-76
EN
In the present study we show FISH localization of 4 porcine BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (SSC4p15), PPARA (SSC5p15), ADIPOR1 (SSC10p13) and CREB (SSC15q24). Until now the CREB and ADIPOR1 genes are considered to be monomorphic, DGAT1 is highly polymorphic, while for the PPARA gene only 1 SNP was identified. Assignment of the studied genes in relation to QTL chromosome regions for meat quality in pig chromosomes SSC4, SSC5, SSC10 and SSC15 is discussed.
3

Cytogenetic mapping of DGAT1, PPARA, ADIPOR1 and CREB genes in the pig

33%
Szczerbal I., Lin L., Stachowiak M., Chmurzynska A., Mackowski M., Winter A., Flisikowski K., Fries R., Switonski M.
Journal of Applied Genetics
|
2007
|
vol. 48
|
issue 1
73-76
EN
In the present study we show FISH localization of 4 porcine BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (SSC4p15), PPARA (SSC5p15), ADIPOR1 (SSC10p13) and CREB (SSC15q24). Until now the CREB and ADIPOR1 genes are considered to be monomorphic, DGAT1 is highly polymorphic, while for the PPARA gene only 1 SNP was identified. Assignment of the studied genes in relation to QTL chromosome regions for meat quality in pig chromosomes SSC4, SSC5, SSC10 and SSC15 is discussed.
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