Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 4

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

Nowe badania nad saponinami ujawniają ich liczne lecznicze właściwości

100%
Sędek Ł., Michalik M.
Kosmos
|
2005
|
vol. 54
|
issue 4
345-356
EN
Saponins (saponosides) belong to a group of secondary metabolites, widely distributed mainly, but not exclusively, among plants. They are reported to occur in over 500 species from over 90 families of both edible and nonedible plants. Chemically, saponins are glycosides consisting of a sugar moiety and non-sugar aglycone, called also sapogenin. Depending on the number of sugar chains attached to the aglycone, mono-, bi- and tridesmosides are distinguished. According to the structure of aglycone, saponins are classified into steroidal and triterpenoid. Common for all types of saponins are their surface-active properties and the ability to form a stable foam in water solutions. This property makes saponins applicable as components of household detergents and fire extinguishers. Saponins have a high ability to bind to cell membrane sterols, which is responsible at least in part for their biological activities. They reveal also strong haemolytic properties, which differ depending on the saponin type and its aglycone structure. Saponins exhibit a wide range of biological properties and are believed to be one of the key biologically active constituents of plant drugs used in folk, especially Far East medicine. Many of the most important saponins are present in the roots of ginseng (Panax ginseng), soybeans (Glycine max) and plants of Bupleurum genus. Saponins are also widely used in conventional medicine (i.e. expectorants, hypocholesterolemic drugs). Moreover many studies in vitro and in vivo exhibited their anti-inflammatory, antimutagenic, antiviral, antibacterial, antifungal, analgesic, and antitumour activities. The latter is the most promising because of its possible future therapeutical application, since many cancer cell lines are more vulnerable to saponins than normal cells. Its cytotoxicity in most cases is the result of apoptosis, nevertheless additional studies including determination of the inhibitory mechanisms of saponins should be addressed.
2
Content available remote

Lclet 4 enhances pro-apoptotic and anti-invasive effects of mitoxantrone on human prostate cancer cells - in vitro study

61%
Koczurkiewicz P., Podolak I., Wójcik K., Galanty A., Madeja Z., Michalik M., Czyż J.
Acta Biochimica Polonica
|
2013
|
vol. 60
|
issue 3
331-338
EN
Triterpene saponosides are widely distributed plant secondary metabolites characterized by relatively low systemic cytotoxicity and a range of biological activities. These include anti-inflammatory, antimicrobial, vasoprotective and antitumor properties. In particular, the ability of saponins to enhance the cytotoxicity of chemotherapeutic drugs opened perspectives for their application in combined cancer chemotherapy. Here, we used human prostate cancer DU-145 cells as an in vitro model to elucidate the synergy of the interactions between biological activities of an oleanane type 13β,28-epoxy triterpene saponoside (Lclet 4) and mitoxantrone, which is a cytostatic drug commonly used in prostate cancer therapy. No cytotoxic or pro-apoptotic effect of Lclet 4 and mitoxantrone administered at the concentrations between 0.05 and 0.1 µg/ml could be seen. In contrast, cocktails of these agents exerted synergistic pro-apoptotic effects, accompanied by the activation of the caspase 3/7 system. This effect was paralleled by attenuating effects of Lclet 4/mitoxantrone cocktails on the invasive potential, metalloproteinase expression and motility of DU-145 cells. Multifaceted and additive effects of Lclet 4 and mitoxantrone on basic cellular traits crucial for prostate cancer progression indicate that the combined application of both agents at systemically neutral concentrations may provide the basis for new promising strategies of prostate cancer chemotherapy.
3
Publication available in full text mode
Content available

Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies

61%
Koczurkiewicz P., Czyż J., Podolak I., Wójcik K., Galanty A., Janeczko Z., Michalik M.
|
|
issue 3
383-393
EN
Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentrations (more than 100 µM) saponins exert cytotoxic and haemolytic effects via permeabilization of the cell membranes. Noteworthy, the inhibition of cancer cell proliferation, the induction of apoptosis and attenuation of cell invasiveness is observed in the presence of low saponin concentrations. Saponins might affect the expression of genes associated with malignancy. These alterations are directly related to the invasive phenotype of cancer cells and depend on "cellular context". It illustrates the relationships between the action of saponins, and the momentary genomic/proteomic status of cancer cells. Here, we discuss the hallmarks of anti-cancer activity of saponins with the particular emphasis on anti-invasive effect of diverse groups of saponins that have been investigated in relation to tumor therapy.
4
Publication available in full text mode
Content available

Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor β1-induced asthmatic bronchial fibroblast-to-myofibroblast transition

52%
Wójcik-Pszczoła K., Hińcza K., Wnuk D., Kądziołka D., Koczurkiewicz P., Sanak M., Madeja Z., Pękala E., Michalik M.
Acta Biochimica Polonica
|
2016
|
vol. 63
|
issue 3
437-442
EN
Bronchial asthma is characterized by persistent airway inflammation and airway wall remodeling. Among many different cells and growth factors triggering changes in bronchi structure, transforming growth factor β1-induced fibroblast to myofibroblast transition is believed to be very important. The aim of this study was to evaluate whether theophylline (used in asthma therapy) and two other methylxanthines (pentoxifylline and its active metabolite lisofylline), may affect transforming growth factor β1-induced fibroblast to myofibroblast transition in bronchial fibroblasts derived from asthmatic patients. We show here for the first time that selected methylxanthines effectively reduce transforming growth factor β1-induced myofibroblast formation in asthmatic bronchial fibroblast populations. PTX was found to be the most effective methylxanthine. The number of differentiated myofibroblasts after PTX, LSF and THEO administration was reduced at least twofold. Studies on the use of methylxanthines opens a new perspective in the development of novel strategies in asthma therapy through their two-pronged, anti-inflammatory and anti-fibrotic action. In the future they can be considered as promising anti-fibrotic drugs.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.