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Thermal barrier coatings (TBCs) are widely used for industrial and aero turbines. The use of residual fuel oil is well known due to economic reasons, which causes hot corrosion. Hot corrosion over extended exposures reduces durability. Therefore, there is a requirement to develop new design approaches for TBCs in order to operate under hot corrosion environment. In this paper, the effect of bond coat thickness on the hot corrosion resistance was studied. Hot corrosion test were carried out in 50 wt.% Na₂So₄+50 wt.% V₂O₅ molten salt at 950°C for 50 hours. The characterizations of the coatings included X-ray diffraction analysis, scanning electron microscopy and optical microscope. Results indicated that TBCs with thick bond coat exhibited superior hot corrosion resistance to the TBCs with conventional bond coat.
EN
The present study concerns responsiveness of pre- and postsynaptic 5-hydroxytryptamine (5-HT)-1A receptors in a rat model of tardive dyskinesia (TD). Vacuous chewing movements (VCMs) in rats are widely accepted as an animal model of TD. Results show that haloperidol injected at a dose of 1 mg/kg twice a day for 5 weeks elicited VCMs, which increased in a time dependent manner following the drug administration for 3-5 weeks. Tolerance was produced in motor coordination during the potentiation of VCMs. Exploratory activity in an open field and in an activity box decreased in haloperidol treated animals. The effects of 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT; 0.5 mg/kg) were monitored 48-h after withdrawal from repeated administration of haloperidol. 8-OH-DPAT-induced locomotion was greater in haloperidol treated rats. 5-HT synthesis increased in haloperidol treated animals, while 8-OH-DPAT-induced decreases of 5-HT synthesis were greater in repeated haloperidol than repeated saline injected animals. The results suggest that an increase in the effectiveness of somatodendritic 5-HT-1A receptors may decrease the inhibitory influence of 5-HT on the activity of dopaminergic neurons to precipitate VCMs. The 5-HT-1A agonist may help to alleviate neuroleptic-induced TD.
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