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1

The role of antisense oligodeoxynucleotides in the investigationa of the molecular phenomenas activated by oncogenes: therapeutical implications

100%
Skorski T., Nieborowska-Skorska M.
Biotechnologia
|
1995
|
issue 1
44-55
EN
Antisense oligodeoxynucleotides are well known as specific inhibitor of targeted genes expression. In this paper we demonmstrate that antisenses could be applied for investigation of the molecular mechanisms activated by oncogenes These studies may identify new targets for antisense treatments of tumors.
2

Antisense oligonucleotides: from the bench to the patients

81%
Skorski T., Nieborowska-Skorska M., Szczylik C., Calabretta B.
Biotechnologia
|
1996
|
issue 4
108-115
EN
We describe here tha current state of progress toward gene-directed antisense-based cancer therapy targeting BCR/ABL, oncogene, primarily from the viewpoint of initial proof-of-concepts studies in animal models of human leukemias and phase I clinical investigations.
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