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1

Heparine - new perspectives of antiinflammatory therapy

100%
Krasnowska M., Kwasniewski A.
Postępy Higieny i Medycyny Doświadczalnej
|
1995
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vol. 49
|
issue 5
661-669
EN
Heparine is used as a therapeutic anticoagulant.Research carried out in the last years showed in both in vivo and in vitro experiments (also in men), that this is a pleiotropic substance with many diverse activities.Immunoregulatory properties of heparine, including immunosupressive and most of all anto-proliferative lead to create the theory of its possible use in sevral chronic inflamatory processes.First experiments seem to justify this opinion.
2

Effect of recombinant IFN-gamma on IgE-dependent leukotriene generation by peripheral blood leukocytes in patients with pollinosis and asthma

81%
Krasnowska M., Medrala W., Malolepszy J., Krasnowski R.
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vol. 48
|
issue 4
287-292
EN
Interferon gamma (IFN-gamma) is considered one of the causative and intensifying factors in inflammation. The reaction to allergens releases IFN-gamma, an immunomodulatory cytokine known to inhibit IgE synthesis and Th cell proliferation. The aim of the study was to evaluate the influence of IFN-gamma on leukotriene (LT) release in vitro, from human leukocytes of atopic patients with pollinosis and asthma. Thirty-eight patients were enrolled in the study: 15 with pollinosis and 23 asthmatics. In the presence of IL-3, leukocytes were stimulated with specific allergens. Other samples of leukocytes were preincubated with different concentrations of IFN-gamma for 15 min before allergen stimulation. The concentration of LT in supernatants was measured according to the CAST-ELISA procedure. We stated that IFN-gamma had significantly diminished LT release in a dose-dependent mode from the leukocytes of pollinotics. IFN-gamma did not change LT release in the asthmatic group, although, in leukocytes the small and medium basic production of LT, IFN-gamma caused a statistically significant fall in LT generation.
3

The role of genetic factors apoptosisi and 14-3-3 protein in the induction of some atopic diseases

71%
Jagiello E., Krasnowska M., Gacko M., Rucinska M., Skrzydlewski Z.
Postępy Higieny i Medycyny Doświadczalnej
|
1997
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vol. 51
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issue 4
385-398
EN
In this review we try to summarize some of the new informations about the genetic base of bronchial asthma. We also mention apoptosis (programmed cell death) as the process modulating cell proliferation, differentiation and death. According to the latest reports, the disorders of the regulation of apoptosis may play an important role an the pathogenesis of autoimmunologic and atopic diseases (including bronchial asthma), AIDS and neoplasmatic diseases. There is a linkage between the induction of apoptosis and signal transduction disorders. We describe the Raf/MECK/ERK/MAP signal transduction pathway and 14-3-3 protein - the peptide which possibly might participate in the initiation of the programmed cell death.
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