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The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory

100%

Wisniewski K., Borawska M., Car H.

Polish Journal of Pharmacology

1993

vol. 45

issue 1

23-29

Angiotensin II (1-8) (A II) and its fragments: angiotensin III (2-8) (A III), angiotensin IV (3-8) (A IV), angiotensin V (4-8) (A V) and angiotensin VI (3-7) (A VI) accelerate acquisition of avoidance response and prolong their extinction. A II fragments are devoid classical A II activities such as the effects on blood pressure and thirst. Alcohol administered chronically (for 9 weeks) depresses the ability to retrieve and acquire avoidance responses. The investigated A II fragments counteract the post-alcohol impairment of learning and memory processes (A V being somewhat less active). Fragments A IV and A VI normalize the retrieval in offspring of mothers exposed to alcohol pre- and post-natally.

The effect of vasopressin analog on learning and memory processes in rats with experimental amnesia

100%

Car H., Borawska M., Wisniewski K.

Polish Journal of Pharmacology

1993

vol. 45

issue 1

11-22

We investigated the effect of a single 2 microg dose of a vasopressin (AVP) analog [d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP on processes of retrieval, consolidation and acquisition of conditioned reflexes in rats with experimentally induced amnesia. The investigated amnesia models were: long term ethanol intoxication, electroconvulsive shocks (ECS), and hypoxia. They all profoundly impaired the learning and memory processes in all tests used. The AVP analog - [d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP facilitated retrieval of passive avoidance in all amnesia models. It improved consolidation of active avoidance of rats previously treated with alcohol, but did not affect the acquisition of active avoidance.[d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP lack antidiuretic properties.

THE EFFECT OF METRONIDAZOLE ON THE VIABILITY OF CAL-27 TONGUE CANCER CELLS.

64%

Tołoczko-Iwaniuk N., Dziemiańczyk-Pakieła D., Celińska-Janowicz K., Drągowski P., Groth D., Reszeć J., Car H., Borys J., Miltyk W.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 75

issue 5

1233-1240

Metronidazole belongs to the most commonly prescribed medications for bacterial and parasitic infections worldwide. It is also used in perioperative prevention prior to bowel, and head and neck surgeries. Despite the fact that the World Health Organization has placed it on its List of Essential Medicines, it is considered potentially carcinogenic. A great number of research studies have been conducted to clarify this issue, but results are inconclusive. None of the studies focused on the influence of metronidazole on oral cancer development. The aim of our study was to evaluate the impact of metronidazole on the viability of tongue cancer cells. The research was conducted on the tongue squamous cell carcinoma cell line (CAL-27). Metronidazole dissolved in growth medium was applied to the cell culture at concentrations: 1, 10, 50, 100μg/mL. Toxicity of the drug was evaluated by MTT assay and the [3H]-thymidine incorporation test. The MTT test revealed a significant increase in cell viability under the influence of metronidazole after 24h, at the highest concentration of the drug (100μg/mL), but had no impact on cell viability at other concentrations and after 48h and 72h. The results of the [3H]-thymidine incorporation test did not show significant results. Summarizing, metronidazole stimulates the viability of tongue squamous cell carcinoma cells according to its concentration and the time of incubation (results significant at the concentration 100μg/mL, after 24 hours of incubation).

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2 Polish Journal of Pharmacology

1 Acta Poloniae Pharmaceutica - Drug Research

1 2018

2 1993

3 Car H.

2 Borawska M.

2 Wisniewski K.

1 Borys J.

1 Celińska-Janowicz K.

1 Drągowski P.

1 Dziemiańczyk-Pakieła D.

1 Groth D.

1 Miltyk W.

1 Reszeć J.

1 Tołoczko-Iwaniuk N.

Search results

The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory

The effect of vasopressin analog on learning and memory processes in rats with experimental amnesia

THE EFFECT OF METRONIDAZOLE ON THE VIABILITY OF CAL-27 TONGUE CANCER CELLS.