Rho kinase (ROCK) belongs to a family of serine/threonine kinases that are activated via interaction with Rho GTPases. ROCK is involved in a wide range of fundamental cellular functions, such as contraction, adhesion, migration, and proliferation. Recent studies have shown that ROCK plays an important role in the regulation of apoptosis in various cell types and animal disease models. Two ROCK isoforms, ROCK1 and ROCK2, are assumed to be function redundant, this based largely on kinase construct overexpression and chemical inhibitors (Y27632 and fasudil) which inhibit both ROCK1 and ROCK2. Gene targeting and RNA interference approaches allow further dissection of distinct cellular, physiological, and patho-physiological functions of the two ROCK isoforms. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling in the regulation of apoptosis and highlights new findings from recently generated ROCK-deficient mice.
Some research has been done on making the compact, portable pulse forming line. A kind of ceramic and a kind of newly developed composite polymer are both used as the dielectric of the planar pulse forming line. The ceramic's dielectric constant ranges from 200 to 600 and the composite polymer's dielectric constant ranges from 100 to 200. It is easier to manufacture the large composite polymer dielectric bulks than to manufacture the ceramic bulks. In the experiments, using the large composite polymer bulk as the dielectric, the planar Blumlein line generated the pulse up to 100 kV with duration 90 ns. Using the ceramic bulk as the dielectric, the planar line generated the voltage pulse up to 60 kV with duration 92 ns.
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.