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Haematological changes in buprenorphine-treated mice

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Banerjee D., Sarkar N. K.

Folia Biologica

1997

vol. 45

157-162

Studies were carried out in adult male Swiss mice to determine whether different haematological parameters like total counts of red and white blood cells, differential counts of white blood cells, haematocrit value and blood haemoglobin level were affected by the synthetic opioid analgesic, buprenorphine, which has currently been known to be abused in several countries by the heroin addicts as a cheap substitute for heroin. The mice were daily given an intraperitoneal injection of buprenorphine (300 mug/kg) for 60 consecutive days. A severe leucopenia accompanied by decreases in lymphocyte and monocyte counts, an increase in neutrophil count, a decrease in haematocrit value, a rossette-like adherence of red blood cells to a few neutrophils and platelet satellitism were observed at the advanced stages of treatment. The abnormalities, however, reverted to normal within 45 days following withdrawal of the drug. The necessity of periodic monitoring of the blood picture in human abusers of the drug is suggested.

Melatonin action on thyroid activity in the soft-shelled turtle, Lissemys punctata punctata

81%

Sarkar S., Sarkar N. K., Bhattacharyya S., Das P.

Folia Biologica

1997

vol. 45

109-112

Adult female turtles (Lissemys punctata punctata) were treated with pineal indoleamine melatonin (100 mug/100 g) or the antithyroid agent, methylthiouracil (100 mug/100 g) or melatonin together with methylthiouracil (100 mug of each drug/100 g) for 12 days. Melatonin alone inhibited thyroid activity as evidenced by reductions in the gland weight, follicular epithelial cell height, thyroid peroxidase, and plasma thyroxine levels. Methylthiouracil caused hyperplasia of the gland, although it inhibited thyroid activity and reduced thyroid peroxidase and plasma thyroxine levels. Melatonin together with methylthiouracil produced changes similar to those obtained with melatonin alone. The results indicate that melatonin probably exerts inhibitory effects influences on both thyrotropin release from the pituitary and the activity of the thyroid itself in turtles.

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2 Folia Biologica

2 1997

2 Sarkar N. K.

1 Banerjee D.

1 Bhattacharyya S.

1 Das P.

1 Sarkar S.

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Haematological changes in buprenorphine-treated mice

Melatonin action on thyroid activity in the soft-shelled turtle, Lissemys punctata punctata