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1

The patch-clamp technique in investigations on T lymphocyte potassium channel modulation

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Teisseyre A.
|
|
issue 3
393-399
EN
This review focuses on results of patch-clamp studies on modulation of T lymphocyte potassium channel activity by physiologically relevant factors. In the preface the patch-clamp technique is briefly presented and basic properties of potassium channels in T lymphocytes are characterised. The paper contains an overview of the data on modulatory effects of extracellular and intracellular pH, temperature, extracellular potassium, extracellular divalent and trivalent metal cations, channel phosphorylation processes and membrane lipid metabolities on potassium channel activity. Some still unresolved problems in that area are indicated.
2

Regulation of human T lymphocyte potassium channel function by intracellular second messengers ? role of calcium, cyclic AMP and membrane lipid metabolities

100%
Teisseyre A.
Postępy Higieny i Medycyny Doświadczalnej
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2000
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vol. 54
|
issue 3
381-390
EN
This review focuses on the influence of well-known intracellular second messengers on the activity of potassium channels expressed in human T lymphocytes. Basic biophysical properties of the channels are briefly presented. Available data on the regulatory role of intracellular calcium and cyclic AMP is reviewed. Finally, a possible influence of lipid compounds, especially high-density lipoproteins, lysophospholipids and sphingolipids, on the expression and activity of potassium channels in human T lymphocytes is discussed.
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