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1

The role of free radicals in pathogenesis of systemic sclerosis

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Komosinska K., Olczyk K., Winsz K.
Postępy Higieny i Medycyny Doświadczalnej
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1997
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vol. 51
|
issue 3
285-303
EN
This article reviews the current concept in the ethiology and pathogenesis of systemic sclerosis. It is suggested that free radicals play a crucial role in pathomechanisms of scleroderma. In addition, the influence of some environmental agents (silica, bleomycin, aalcohol, toxic oil) on free radical production and subsequent induction of scleroderma or scleroderma-like syndrome is also described.
2

Free radical concepction of etiopathogenesis of Graves-Basedow disease

100%
Komosinska-Vassev K., Olczyk K., Winsz K.
Postępy Higieny i Medycyny Doświadczalnej
|
2000
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vol. 54
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issue 2
225-237
EN
Increased metabolism due to hyperthyroidism leads to the dysfunction of the mitochondria respiratory chain, resulting in elevated formation of the reactive oxygen species in the course of Graves-Basedov disease. It has also been reported that excessive thyroid hormone level may induce oxidative tissue injury. Furthermore, Graves-Basedow disease is frequently associated with changes of the antioxidant defence system activity. The disturbed balance between oxidative and antioxidative processes may be of significant importance in the pathogenesis of Graves-Basedow disease.
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