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Complexity of class II genes ? the regulation of transcription

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Dullin P., Galbas M., Glanc P., Walerych W.
Biotechnologia
|
2002
|
issue 3
107-123
EN
The control of eucaryotic class II genes transcription is unusually complicated because it is the first stage of their expression in the cell. The assortment of specific gene coding sequence as a process of selection of submission for expression genes particularly essential is. In this process, beside RNA polymerase II, the basic transcription initiation factors that form different initiation complexes with enzyme and DNA take part, as well as other protein factors, often tissue specific that interact with fragment of DNA located in the distant place of the start of transcription. The formation of transcription complex, its components and possible interaction are discussed. The control of this process are discussed on the example of contribution of protein kinases and phosphatases modifying individual proteins, influencing the change of their mutual interactions and, in consequence, differentiating transcription level of specific genes.
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