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1

Selenium in the cytotoxicity of cisplatin

100%
Olas B., Wachowicz B.
Postępy Higieny i Medycyny Doświadczalnej
|
1997
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vol. 51
|
issue 1
95-108
EN
Cisplatin is a widely used chemotherapeutic agent, highly effective in the treatment of various types of human malignancies. The antitumor activity of cisplatin is attributed mainly to its ability to form adducts with DNA. Cisplatin may react with proteins and also with glutathione forming complex GS-Pt. This agent causes haematological, neurological toxicity and changes function of different cells. Recently, is has been reported that administration of sodium selenite reduces cisplatin toxicity without inhibiting the antitumour activity of cisplatin. This review focuses on the mechanism of cisplatin - induced cytotoxicity and the protective role of selenium.
2

Biological activity of resveratrol

100%
Olas B., Wachowicz B.
Postępy Higieny i Medycyny Doświadczalnej
|
2001
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vol. 55
|
issue 1
71-79
EN
Resveratrol is a phytoalexin found in many plants, mainly in grapes. It has been shown to prevent coronary heart diseases ant to exert a variety of anti-cancer and anti-inflammatory effects.
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