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Analysis of the structure - anticancer activity relationship in a set of Schiff bases of macrocyclic 2,6-bis(2- and 4-formylaryloxymethyl)pyridines.

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Kuz'min V. E., Lozitsky V. P., Kamalov G. L., Lozitskaya R. N., Zheltvay A. I., Fedtchouk A. S., Kryzhanovsky D. N.

Acta Biochimica Polonica

2000

vol. 47

issue 3

867-875

Quantitative estimation of the structure - anticancer activity relationship in a series of macrocyclic Schiff bases of 2,6-bis(formylaryloxymethyl)pyridines was carried out by the topological approach. Correlation equations describing the relationship between the anticancer activity and structural parameters of the molecules studied and descriptors characterizing their structure were obtained on the basis of in vitro screening data. The influence of structure of the investigated substances as reflected by the parameters studied on the anticancer activity, was established.

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1 Acta Biochimica Polonica

1 2000

1 Fedtchouk A. S.

1 Kamalov G. L.

1 Kryzhanovsky D. N.

1 Kuz'min V. E.

1 Lozitskaya R. N.

1 Lozitsky V. P.

1 Zheltvay A. I.

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Analysis of the structure - anticancer activity relationship in a set of Schiff bases of macrocyclic 2,6-bis(2- and 4-formylaryloxymethyl)pyridines.