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Memory for object and object-location after lesions to the ventromedial prefrontal cortex in humans

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Szatkowska I., Grabowska A., Szymanska O.

Acta Neurobiologiae Experimentalis

2003

vol. 63

issue 1

31-38

The aim of the present study was to investigate the effect of small unilateral lesions to the ventromedial portion of the prefrontal cortex on two memory functions: memory for objects and memory for object locations. Patients, who had undergone surgery of the anterior communicating artery aneurysm, and normal control subjects, participated in the study. The patients were subdivided into two groups: with and without unilateral resection of the gyrus rectus. Subjects were presented with two memory tests, that required remembering either simultaneously presented visual stimuli (object memory test; OMT) or locations of the stimuli (location memory test; LMT). In the OMT, patients with resection of the gyrus rectus were impaired in comparison to patients without resection and normal control subjects. In the LMT, the three groups did not differ from each other. Our results suggest that the ventromedial prefrontal cortex is specifically involved in memory for objects.

Phonological and semantic fluencies are mediated by different regions of the prefrontal cortex

88%

Szatkowska I., Grabowska G. A., Grabowska A., Szymanska S. O., Szymanska O.

Acta Neurobiologiae Experimentalis

2000

vol. 60

issue 4

503-508

Verbal phonological and semantic fluencies were investigated in 24 patients with unilateral prefrontal lesions and 10 normal control subjects. Lesions were limited to small areas within either the dorsolateral (Brodmann?s area 46/9) or ventromedial (posterior part of the gyrus rectus) cortices. In a phonological fluency task, patients with lesions to the left dorsolateral region were impaired. In semantic fluency, not only the left dorsolateral group but also the two right frontal damaged groups performed worse than the control group. In agreement with previous studies, our results show that the phonological fluency is mediated by the left dorsolateral prefrontal cortex. In contrast to this, performance on the semantic fluency task depends on a wider portion of the prefrontal cortex involving the left and right dorsolateral and the right ventromedial areas.

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2 Acta Neurobiologiae Experimentalis

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Memory for object and object-location after lesions to the ventromedial prefrontal cortex in humans

Phonological and semantic fluencies are mediated by different regions of the prefrontal cortex