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Spectrum of Cancers Diagnosed in the Families Carrying Germline Mutation inBRCA 1/2Genes

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Budryk M., Tęcza K., Grzybowska E.
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issue 10
453-456
EN
The aim of the genetic tests and counseling done at the Centre of Oncology-MSC Institute in Gliwice is to screen for the carriers of germline mutations in BRCA1 and BRCA2 genes who belong to the group of high risk of developing malignancy.Material and methods. The risk of breast and/or ovary cancer among the carriers of germline mutations in BRCA1 and 2 genes is 40-90%. The patients are qualified to genetic test for HBOC syndrome not only according to the family history of cancers criteria which allow to find families with high risk of developing cancer.Results. At Genetic Counseling we find mutations in 5% of persons referred to genetic tests. Germline mutations were also found in families which did not meet clinical criteria for HBOC.Conclusion. These findings justify the need to screen for BRCA mutations also persons without strong family history of breast and ovary cancers.
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Direct transfer of IL-12 gene into growing Renca tumors.

100%
Budryk M., Wilczyńska U., Szary J., Szala S.
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2000
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vol. 47
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issue 2
385-391
EN
We investigated the feasibility of transferring naked plasmid DNA containing a therapeutic gene (IL-12) into mice harboring growing Renca tumors. We found that naked DNA transferred into growing Renca and B16(F10) tumors gives higher expression level of reporter gene than complexes of DNA with DDAB/ DOPE or DC-Chol/DOPE. Transfer of naked DNA carrying the IL-12 gene into growing Renca tumors causes a distinct therapeutic effect that depends on the time span between inoculation of mice with cancer cells and the beginning of the therapy. Therapy started on day 3 resulted in total cure (100%) of mice.
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Direct in vivo transfer of plasmid DNA into murine tumors: Effects of endotoxin presence and transgene localization.

100%
Budryk M., Cichoń T., Szala S.
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EN
The purpose of this study was to investigate the effect of endotoxin presence in plasmid DNA preparations on the efficiency of transfection achieved in vivo with B16(F10) and Renca tumors and to determine transgene localization. Our data show that endotoxin markedly decreases the efficiency of transfection. Furthermore, the transgene transferred in vivo can be found in both neoplastic and normal (most likely myofibroblast) cells lying in proximity of the administration site.
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