Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 3

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1
Content available remote

Influence of Location and Mitotic Index on Prognosis in Patients with Gastrointestinal Stromal Tumors

100%
Mrowiec S., Jabłońska B., Leidgens M., Pająk J., Lampe P.
Polish Journal of Surgery
|
2008
|
vol. 80
|
issue 6
321-330
EN
Gastrointestinal stroma tumors (GIST) arise from the pacemaker, the interstitial Wells of Cajal. These tumors constitute 1 to 3% of gastrointestinal neoplasms, and may occur in each portion of the gastrointestinal tract. The most useful prognostic factors are tumor size, mitotic index, cell structure and location within the gastrointestinal tract.The aim of the study was to assess the chosen prognostic factors (location in the gastrointestinal tract and mitotic index) in patients with GIST.Material and methods. Between 1989 and 2002, 74 patients (37 men and 37 women) with an average age of 54.9 years (range from 13 to 89 years) were operated for GIST in the Department of Gastrointestinal Surgery. Two- and five-year survival rates during observation were analyzed, as well as the location within the gastrointestinal tract and mitotic index. Based on the intraoperative and postoperative investigations, the tumor size, presence of metastases and histological type of predominant cells were estimated in each patent. Results were subjected to statistics, where p≤0.05 was considered to be significant.Results. Of the 74 patients included in the study, 3 patients (4%) had a primary tumor located in the lower oesophagus, 42 patients (56.8%) in the stomach, 4 patients (5.4%) in the duodenum, and 13 patients (17.6%) had tumors originated from the small intestine. In an additional 12 patients (16.2%), the tumor originated from the large intestine. The most frequent (51%) mitotic index was 2, and 9/50 hpf was considered an intermediate malignant potential risk. Two-year survival was common in patients with GIST located in the oesophagus, stomach, and duodenum, totalling 34 (79%) patients. A lower than two-year survival rate was noted in patients with GIST arising from the small intestine: 7 (63.6%) patients had tumors arising from the colon and 4 (36.3%) patients had rectal tumors. Five-year survival was also the most frequent in patients with GIST located in the upper part of gastrointestinal tract (37.2%), in the median part of gastrointestinal tract (36.3%), and in the lower part of the gastrointestinal tract (27.7%). Correlation between location, mitotic index and survival of patients was assessed. The correlation studies showed a statistically significant influence of tumor location in the gastrointestinal tract (p=0.0264) and mitotic index (p=0.0003) with the survival of patients operated for GIST. Thus, the lower location and higher mitotic index of GIST are associated with shorter survival of patients.Conclusions. The mitotic index and location in the gastrointestinal tract are essential prognostic factors in analyzed patients with GIST. In the analyzed group, the lower locations and higher mitotic indices of GIST were associated with shorter survival of patients.
2
Content available remote

Quality of Life of Patients Following Pylorus-Sparing Pancreatoduodenectomy

100%
Musiewicz M., Lampe P., Mrowiec S., Ciosek J., Grabarczyk A.
Polish Journal of Surgery
|
2008
|
vol. 80
|
issue 7
351-363
EN
Quality of life after pancreatoduodenectomy (PD) for cancer of the head of the pancreas depends on multiple factors. Handling of the pancreatic remnant is a decisive factor for the success of the operation. The aim of the study is to assess quality of life of patients with cancer of the head of the pancreas undergoing pylorus-sparing PD and reconstruction with pancreaticojejunostomy (PJ) versus pancreaticogastrostomy (PG).Material and methods. An analysis was performed for 115 patients with malignancy of the head of the pancreas who underwent surgical treatment in the Department of Gastrointestinal Surgery Medical Academy of Silesia between 2004 and 2006. Quality of life was assessed with the EORTC QLQ-C30 and QLQ-PAN26 forms. These questionnaires were mailed to 34 patients at least 6 months after PD. The 20 patients who returned correctly completed questionnaires were divided into two groups. Group I included 14 patients after PD with (Traverso or Imanaga) PJ. Group II included six patients after PD with Flautner PG.Results. The study groups were homogeneous with respect to age, gender, preoperative and intraoperative factors, and complications. Better quality of life was observed in group I with respect to the cognitive functions, general fatigue, and insomnia scales., Group II exhibited better quality of life with respect to the physical functioning, social functioning, life activity, general health, dyspeptic symptoms, nausea and vomiting, diarrhea, respiratory disturbances, lack of satisfaction with own appearance, taste changes, liver symptoms, decreased muscle strength, indigestion, dry mouth and treatment of emergent side-effects scales.Conclusions. Patients in the study group following PD and Flautner PG exhibit markedly better quality of life.
3
Content available remote

Gastric Emptying in Esophageal Substitutes

86%
Mrowiec S., Dobija M., Nalewajka-Kołodziejczak J., Kasicka-Jonderko A., Jonderko K., Nowak S., Lampe P.
Polish Journal of Surgery
|
2008
|
vol. 80
|
issue 7
343-350
EN
For patients undergoing esophagectomy, the stomach is the organ that is most commonly used to restore continuity in the gastrointestinal tract. As a consequence of changes in stomach shape and location, patients in the postoperative period usually experience disturbed motility of the upper gastrointestinal tract of variable intensity.The aim of the study was to assess the motility of esophageal substitutes and the emptying rate of a narrowed stomach (in particular its prepyloric portion) using scintigraphy in patients undergoing esophageal resection compared to those in healthy controls.Material and methods. Between 2000 and 2006, 297 patients (105 women, 192 men) underwent surgical treatment for esophageal cancer in the Clinic of Gastrointestinal Surgery. Ten patients (average age 59; range 54 to 67 years) who underwent an attempted curative esophageal resection were selected into the study group. Patients from this group underwent scintigraphic assessment of gastric emptying between three to 11 months after the surgical procedure (an average 7 months). Furthermore, ten healthy volunteers (average age 28; range 19 to 43 years) constituted the control group.Results. The average radiotracer retention after two hours was 44.7±6.5% in the study group and 51.1±7.4% (p>0.2) in the control group. Frequency of contractions of the whole prepyloric segment, as well as its distal fragment, in the subsequent periods of examination was comparable in both groups. Correlation among the frequency of contractions, contraction duration and duration of relaxation of the whole prepyloric segment and its distal fragment was high for the control group (correlation coefficients 0.71 p<0.001; 0.71 p=0; and 0.63 p=0, respectively). In the study group, correlation between the frequency of contractions and contraction duration was poor (coefficients of correlation 0.03 p>0.8 and -0.02 p>0.9), while correlation between duration of relaxation of the whole prepyloric segment and its distal fragment was moderate (coefficient of correlation 0.34 p>0.06).Conclusions. Formation of a gastric substitute after its narrowing and denervation (truncal vagotomy) does not abolish gastric contractility. Frequency, amplitude, duration of contraction, and relaxation duration of the prepyloric portion of the ectopic substitute do not differ significantly from the patterns of motility of the upper gastrointestinal tract in healthy volunteers.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.