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Novel Synthesis, spectral, characterization of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole and its applications of molecular docking, anticancer activity

100%
Dhineshkumar E., doss M. A., Uma D.
World News of Natural Sciences
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2020
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vol. 30
|
issue 2
203-212
EN
In the present study of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole 1 was synthesized. The synthesized imidazole compound 1 has been characterized by FT-IR, 1H, 13C NMR and ESI-Mass spectral studies. Molecular docking is also performed in order to explain the over-expression of estrogen receptor in 70% of liver cancer. The imidazole scaffold is a privileged scaffold for exploration of anticancer agents. The objective of the present study is to evaluate the anticancer activity of imidazole 1 in human liver cancer cell lines HepG2.
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Design and Antimicrobial evaluation of 1-(2-(2,3,5-triphenylcyclopenta-2,4-dien-1-yl)ethyl)piperazine and their derivatives

88%
doss M. A., Rajkumar R., Prabhakaran A., Dhineshkumar E., Uma D.
World News of Natural Sciences
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2020
|
vol. 30
|
issue 2
213-219
EN
A total of six of 1,2,4,5-tetrasubstituted imidazoles were prepared by multicomponent cyclo- condensation of benzil, aromatic aldehyde, aminoethylpiperazine and ammonium acetate. The prepared compounds were screened for their antibacterial activity against S. aureus, S. typhi, E.coli and Pseudomonas and antifungal activity against A. niger, C. albicans, Rhizopus sp, and Mucor. They exhibited better activities against all the tested bacterial and fungal strains.
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