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Trudności w leczeniu zakażeń pooperacyjnych – opis przypadku

100%
Różalska M., Józefowicz-Korczyńska M.
Polish Journal of Otolaryngology
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2008
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vol. 62
|
issue 6
776-778
EN
Postoperative wounds infections due to surgical intervention of laryngeal cancer are serious therapeutic problem. This process led to the necrosis of surrounding tissues and in consequence prolongs the wounds healing and cause longer hospitalisation, delay of vocal rehabilitation and cause chronic infl ammation of trachea and bronchi. We investigated a cause of patient after surgical intervention. Postoperative wound as well as upper respiratory tracts of this patient were colonized by methicillinresistant Staphylococcus aureus (MRSA). The following symptoms of in infl ammation were noticed: subfebrile condition, muscles and joints pain, excessive secretion of mucus in respiratory tracts and malaise. Patient was treated many times (repeatedly) with antibiotics and chemotherapeutics ambulatory and during hospitalisation. The susceptibility to antibiotics and chemotherapeutics to isolated MRSA strain was established. The effective therapy occurred using combine of rifampicin and co-trimoxasole. The patient status was radically improved. Patient after therapy was monitored microbiologically for a several month and in clinical material isolated from him did not found MRSA.
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Synergistic hemolysins of coagulase-negative staphylococci (CoNS)

81%
Różalska M., Derczyńska A., Maszewska A.
Acta Biochimica Polonica
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2015
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vol. 62
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issue 4
757-764
EN
A total of 104 coagulase negative staphylococci, belonging to S. capitis, S. hominis, S. haemolyticus and S. warneri, originating from the collection of the Department of Pharmaceutical Microbiology (ZMF), Medical University of Lodz, Poland, were tested for their synergistic hemolytic activity. 83% of strains produced δ-hemolysin, however, the percentage of positive strains of S. haemolyticus, S. warneri, S. capitis and S. hominis was different - 98%, 78%, 75% and 68%, respectively. Highly pure hemolysins were obtained from culture supernatants by protein precipitation with ammonium sulphate (0-70% of saturation) and extraction by using a mixture of organic solvents. The purity and molecular mass of hemolysins was determined by TRIS/Tricine PAGE. All CoNS hemolysins were small peptides with a molar mass of about 3.5 kDa; they possessed cytotoxic activity against the line of human foreskin fibroblasts ATCC Hs27 and lysed red cells from different mammalian species, however, the highest activity was observed when guinea pig, dog and human red blood cells were used. The cytotoxic effect on fibroblasts occurred within 30 minutes. The S. cohnii ssp. urealyticus strain was used as a control. The antimicrobial activity was examined using hemolysins of S. capitis, S. hominis, S. cohnii ssp. cohnii and S. cohnii ssp. urealyticus. Hemolysins of the two S. cohnii subspecies did not demonstrate antimicrobial activity. Cytolysins of S. capitis and S. hominis had a very narrow spectrum of action; out of 37 examined strains, the growth of only Micrococcus luteus, Corynebacterium diphtheriae and Pasteurella multocida was inhibited.
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